5-Methoxy-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

Base Information

• Chemical Name: 5-Methoxy-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
• CAS No.: 59264-10-7
• Molecular Formula: C7H10N2O3
• Molecular Weight: 170.1659
• NSC Number: 118991
• DSSTox Substance ID: DTXSID80297895
• Nikkaji Number: J1.986.117A
• Wikidata: Q82039392
• Mol file: 59264-10-7.mol

Synonyms:59264-10-7;5-methoxy-1,3-dimethylpyrimidine-2,4-dione;5-Methoxy-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione;5-Methoxy-1,3-dimethylpyrimidine-2,4(1H,3H)-dione;5-Methoxy-1,3-dimethyluracil;NSC118991;DTXSID80297895;HLNJGHKPYRXTKU-UHFFFAOYSA-N;NSC-118991;2,4(1H,3H)-Pyrimidinedione, 5-methoxy-1,3-dimethyl-;5-Methoxy-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione #

Chemical Property of 5-Methoxy-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

Chemical Property:

• Vapor Pressure: 0.0142mmHg at 25°C
• Boiling Point: 257.8°Cat760mmHg
• Flash Point: 109.7°C
• PSA: 53.23000
• Density: 1.28g/cm³
• LogP: -0.90740
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 170.06914219
• Heavy Atom Count: 12
• Complexity: 259

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C=C(C(=O)N(C1=O)C)OC

Technology Process of 5-Methoxy-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

There total 3 articles about 5-Methoxy-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxyuracil (20636-41-3) + methyl iodide (74-88-4) → 5-methoxy-1,3-dimethyluracil (59264-10-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 4h; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.molcatb.2011.11.014

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 5-hydroxyuracil (20636-41-3) → 5-methoxy-1,3-dimethyluracil (59264-10-7)

Guidance literature:

With diethyl ether;

Reference yield:

5-hydroxyuracil (20636-41-3) + dimethyl sulfate (77-78-1) → 5-methoxy-1,3-dimethyluracil (59264-10-7)

Guidance literature:

With potassium hydroxide;

upstream raw materials:

diazomethane

5-hydroxyuracil

dimethyl sulfate

methyl iodide

Downstream raw materials:

1,3-dimethyl-5-hydroxyuracil