Phenol, 2-(1,4-diphenyl-1H-pyrazol-5-yl)-

Base Information

Chemical Name:Phenol, 2-(1,4-diphenyl-1H-pyrazol-5-yl)-
CAS No.:65190-70-7
Molecular Formula:C21H16N2O
Molecular Weight:312.371
Hs Code.:

Synonyms:

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Chemical Property of Phenol, 2-(1,4-diphenyl-1H-pyrazol-5-yl)-

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Technology Process of Phenol, 2-(1,4-diphenyl-1H-pyrazol-5-yl)-

There total 10 articles about Phenol, 2-(1,4-diphenyl-1H-pyrazol-5-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 290353-18-3
5-(2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole

: 65190-70-7
1,4-diphenylpyrazole-5-(2-hydroxyphenyl)pyrazole

Guidance literature:: 5-(2-hydroxyphenyl)-4-(2-iodophenyl)-1-phenylpyrazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo025767j

Reference yield:

: 19820-56-5
2-formylphenyl tosylate

: 65190-70-7
1,4-diphenylpyrazole-5-(2-hydroxyphenyl)pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / H₂O; acetonitrile / 10 h / 20 °C

2.1: NaH / dimethylformamide / 3.5 h / -19 °C

3.1: conc.HCl / methanol; H₂O / 110 °C

4.1: 46 percent / toluene / 90 °C

5.1: 90 percent / Na₂CO₃; HOAc / methanol; H₂O / 5 h / 145 °C / pH 4

6.1: 88 percent / NaOH; triethylbenzylammonium chloride / H₂O; methanol / 9 h / 140 °C

7.1: n-BuLi / tetrahydrofuran; various solvent(s) / -78 °C

7.2: 71 percent / trimethylborate / tetrahydrofuran; various solvent(s) / -78 - 20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 59-88-1
phenylhydrazine hydrochloride

: 65190-70-7
1,4-diphenylpyrazole-5-(2-hydroxyphenyl)pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / Na₂CO₃; HOAc / methanol; H₂O / 5 h / 145 °C / pH 4

2.1: 88 percent / NaOH; triethylbenzylammonium chloride / H₂O; methanol / 9 h / 140 °C

3.1: n-BuLi / tetrahydrofuran; various solvent(s) / -78 °C

3.2: 71 percent / trimethylborate / tetrahydrofuran; various solvent(s) / -78 - 20 °C

With sodium hydroxide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo025767j