3,5-Dichloro-4-hydroxybenzophenone

Base Information

• Chemical Name: 3,5-Dichloro-4-hydroxybenzophenone
• CAS No.: 34183-06-7
• Molecular Formula: C13H8Cl2O2
• Molecular Weight: 267.111
• Hs Code.: 2914700090
• European Community (EC) Number: 251-866-3
• UNII: 2X5HWV7QBK
• DSSTox Substance ID: DTXSID20187781
• Nikkaji Number: J88.917B
• Wikidata: Q83059524
• Mol file: 34183-06-7.mol

Synonyms:3,5-Dichloro-4-hydroxybenzophenone;34183-06-7;(3,5-dichloro-4-hydroxyphenyl)-phenylmethanone;EINECS 251-866-3;2X5HWV7QBK;C13H8Cl2O2;Methanone, (3,5-dichloro-4-hydroxyphenyl)phenyl-;UNII-2X5HWV7QBK;Methanone,(3,5-dichloro-4-hydroxyphenyl)phenyl-;SCHEMBL10893926;DTXSID20187781;4-BENZOYL-2,6-DICHLOROPHENOL;AKOS017553371;(3,5-dichloro-4-hydroxyphenyl)phenylmethanone;EN300-1276680

Chemical Property of 3,5-Dichloro-4-hydroxybenzophenone

Chemical Property:

• Vapor Pressure: 2.97E-07mmHg at 25°C
• Refractive Index: 1.631
• Boiling Point: 408.4 °C at 760 mmHg
• Flash Point: 200.8 °C
• PSA: 37.30000
• Density: 1.406 g/cm³
• LogP: 3.93000
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 265.9901349
• Heavy Atom Count: 17
• Complexity: 265

Purity/Quality:

99% ^*data from raw suppliers

3,5-DICHLORO-4-HYDROXYBENZOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)Cl)O)Cl

Technology Process of 3,5-Dichloro-4-hydroxybenzophenone

There total 10 articles about 3,5-Dichloro-4-hydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-benzyl-2,6-dichloro-phenol (38932-58-0) → (3,5-dichloro-4-hydroxyphenyl)(phenyl)methanone (34183-06-7)

Guidance literature:

With oxygen; cobalt(II) diacetate tetrahydrate; sodium hydroxide; In ethylene glycol; at 100 ℃; for 18h; under 760.051 Torr;

DOI:10.1007/s11164-014-1801-8

Reference yield:

2,6-Dichlorophenyl benzoate (107931-00-0) → (3,5-dichloro-4-hydroxyphenyl)(phenyl)methanone (34183-06-7)

Guidance literature:

With aluminium trichloride; at 155 ℃;

DOI:10.1021/ja01251a046

Reference yield:

2,6-Dichlorophenol (87-65-0) → (3,5-dichloro-4-hydroxyphenyl)(phenyl)methanone (34183-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: AlCl₃ / 155 °C

With pyridine; aluminium trichloride;

DOI:10.1021/ja01251a046

upstream raw materials:

2,6-Dichlorophenyl benzoate

3,5-dichloro-4-methoxy-benzophenone

4-Hydroxybenzophenone

aluminium trichloride

Downstream raw materials:

2,6-Dichloro-4-(hydroxy-phenyl-methyl)-phenol

Refernces