Synonyms:Aluminumchloride (8CI);
99% *data from raw suppliers
Aluminum chloride *data from reagent suppliers
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There total 236 articles about Aluminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The research focuses on the synthesis of a novel monosubstituted ferrocene-based chiral Schiff's base derivative, which exhibits unusual mesomorphic behavior. This compound is the first metallomesogen to display twist-grain boundary phases (TGBA) and blue phases, in addition to the more common smectic C* (SC*), smectic A (SA), and nematic (N*) phase transformations. The purpose of this study was to explore the potential of chiral metallomesogens in liquid crystal research, particularly those incorporating ferrocene units, which could lead to materials with high thermal stability and unique electronic properties. The researchers synthesized the chiral Schiff's base derivative using a series of chemical reactions involving compounds such as AlCl3, BuNH2?BH3, p-HOC6H4CO2Me, KOH HCl, p-HOC6H4NO2, DCC, and Pd(10%)C. The final compound, named compound 8, was obtained by refluxing equimolar amounts of intermediates 6 and 7 in ethanol containing a few drops of acetic acid, followed by filtration and reprecipitation. The study concluded that this ferrocene derivative and its analogs could be promising candidates for the development of ferroelectric smectic C* materials, which have potential applications in fast-switching electro-optic devices.
The research focuses on the exploration of a new route to synthesize disubstituted 2'-hydroxypropiophenones using titanium tetrachloride induced Fries rearrangement. The purpose of this study was to develop a convenient method for the synthesis of hindered dialkyl 2'-hydroxypropiophenones, which are important intermediates for pharmaceutical applications. The researchers utilized various dialkylphenyl propionates and phenols as starting materials, with titanium tetrachloride and aluminum chloride serving as catalysts to achieve the rearrangement and subsequent elimination reactions. The conclusions drawn from the study indicate that the sequential use of these reagents allowed for the synthesis of previously unknown 3',6'- and 5',6'-dialkyl-2-hydroxypropiophenones, demonstrating the effectiveness of the method in producing these compounds. The research also highlighted the importance of understanding the electronic and steric effects on the reaction outcomes, as well as the role of the catalysts in influencing the reaction pathways.
The research discusses the use of zinc selenolates for nucleophilic cleavage of lactones and esters, utilizing a method that involves the generation of zinc selenolate from diselenides in the presence of Zn/AlCl3. The study aimed to develop a mild and neutral synthetic procedure that avoids the use of hazardous solvents and strong bases. The main reactants in the experiments were diaryl diselenides, zinc dust, anhydrous aluminum chloride, and various lactones or esters. The reactions were conducted in dry acetonitrile at 70°C under aerial conditions. The products were characterized using techniques such as 1H and 13C NMR, IR spectroscopy, mass spectroscopy, and elemental analysis, yielding carboxylic acids with moderate to excellent yields. The research demonstrated that zinc selenolate is an effective reagent for SN2-type cleavage of lactones and esters under relatively mild conditions, offering advantages in terms of operational simplicity and cost over previously reported methods.
The research focuses on the utilization of hydrotalcite catalysis for the synthesis of novel chiral building blocks, specifically lactones 7 and 8, derived from carvone. The methodology involves a regioselective Baeyer–Villiger reaction using hydrogen peroxide as the oxidant and hydrotalcites as catalysts, which is considered green due to the lack of by-products other than water. The study compares different reaction conditions, including the use of AlCl3 and meta-chloroperbenzoic acid (m-CPBA) as oxidants, and evaluates the efficiency of the catalysts in terms of yield and selectivity. Reactants such as carvone, benzonitrile, and various catalysts were used, and the progress of reactions was monitored by thin-layer chromatography (TLC). Analyses of the synthesized compounds were conducted using techniques like infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) to determine their structures and confirm their formation.
The research focuses on the facile synthesis of racemic 2-aminomethyl-4-oxo-piperidine intermediates, which are crucial for constructing the piperidine nucleus found in various natural products and drug candidates. The synthesis involves a three-component hetero Diels-Alder reaction using an appropriately functionalized imine and 2-trimethylsiloxy-1,3-butadiene, which allows for the installation of protecting groups for both the piperidine and 2-position side chain nitrogens in a single step, and avoids a reduction step, thus providing rapid entry into the piperidine core structure. The experiments utilized various catalysts to optimize the reaction conditions, with aluminum chloride proving to be the most effective, yielding the desired product in 37%. The synthesized intermediates were then transformed into fully protected 2-aminomethyl-4-oxopiperidine compounds through additional reactions. The analyses included NMR spectroscopy and melting point determination to characterize the compounds, with the final products isolated through flash chromatography.
The research focused on synthesizing a series of 12 new Mannich bases derived from 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones, aimed at evaluating their potential as antineoplastic agents. The study utilized chemicals such as acetyl chloride, aluminum chloride, dimethylformamide (DMF), formaldehyde, and various secondary amines in the synthesis process. The cytotoxicity of the synthesized compounds was assessed using the MTT assay on human pre-B-cell leukemia cell line BV-173 and chronic myeloid leukemia cell line K-562. The results indicated that the Mannich bases exhibited concentration-dependent cytotoxic effects, with some compounds inducing programmed cell death at low micromolar concentrations. The findings suggest that these heterocyclic chalcones represent a promising class of cytotoxic agents, warranting further pharmacological evaluation to elucidate their mechanisms of action and structure-activity relationships.
The research describes the synthesis and structural characterization of a novel trimer derived from the reaction of ageratochromene II with anhydrous aluminum chloride. The purpose of the study was to explore the reaction and provide a detailed structural description of the resulting trimer, which may have potential as an antijuvenile hormone. The researchers used various analytical techniques, including NMR (1H, 13C, DEPT-135, COSY, HMBC, HSQC, TOCSY, and NOESY), IR, mass spectrometry, and elemental analysis, to confirm the structure of the trimer. The conclusion was that the unexpected solid isolated from the reaction was indeed a trimer of ageratochromene II, with a molecular formula of C39H48O9, and its structure was consistent with all spectral data obtained. The chemicals used in the process included ageratochromene II, anhydrous aluminum chloride, diethyl ether, ice-water, brine, anhydrous sodium sulfate, and silica gel for chromatography, as well as light petroleum and diethyl ether for the purification and recrystallization steps.
The research focuses on synthesizing unsymmetrical 2,4-diaryl- and 2,3-diarylthiophenes starting from 2,5-dichlorothiophene. The purpose is to explore the chemistry of thiophene-containing analogs, which have not been fully investigated compared to oligophenylenes, and to develop a new route to synthesize mixed thiophene-arene oligomers containing 2,3- and 2,4-thienylene units. Key chemicals used include 2,5-dichlorothiophene as the starting material, aluminum chloride as a catalyst, arylmagnesium iodide for cross-coupling reactions, and bis(acetylacetonato)nickel(II) as a mediator. The study concludes that 2,5-dichlorothiophene is a versatile precursor for these syntheses. The researchers successfully synthesized the target compounds in reasonable yields and characterized them using various spectroscopic techniques. They also observed an unusual formation of 2,4-diarylthiophenes from 3-aryl-2-chlorothiophenes in the presence of aluminum chloride and aromatic ethers, which contrasts with typical reactions of other chlorothiophenes.
The research explores the use of benzeneseleninyl chloride as an effective reagent for the vinylic chlorination of olefins under mild conditions in the presence of a Lewis acid, specifically aluminum chloride. The study demonstrates that benzeneseleninyl chloride can be employed to chlorinate olefins in a single step, yielding chlorinated products at the vinyl position with good yields. The reaction mechanism involves the formation of a cyclic selenoxonium ion intermediate, which is subsequently attacked by a chloride ion to produce the final chlorinated product. The researchers also observed that certain olefins, such as styrene, trans-stilbene, and trans-1-phenylpropene, formed dichloro adducts under similar conditions, suggesting a different reaction pathway involving a positive chlorine intermediate.
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