AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one

Base Information

• Chemical Name: AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one
• CAS No.: 6152-57-4
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• Mol file: 6152-57-4.mol

Synonyms:3-Methoxy-4-phenylcarbostyril;3-Methoxy-4-phenyl-1H-chinolin-2-on;3-O-Methylviridicatin;

Chemical Property of AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one

Chemical Property:

• Vapor Pressure: 3.02E-09mmHg at 25°C
• Boiling Point: 476.5°Cat760mmHg
• Flash Point: 242°C
• PSA: 42.35000
• Density: 1.25g/cm³
• LogP: 3.61600
• Solubility.: Soluble in DMSO

Purity/Quality:

≥99% ^*data from raw suppliers

O-Methylviridicatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-O-Methylviridicatin is a metabolite produced by several species of Penicillium. Recently, 3-O-methylviridicatin was shown to be a strong inhibitor of TNFα-induced replication of HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite.

Technology Process of AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one

There total 11 articles about AIDS-089094, 3-Methoxy-4-phenyl-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-methoxy-4-phenyl-1-tosylquinolin-2(1H)-one (1372126-07-2) → 3-methoxy-4-phenyl-quinoline-2(1H)-one (6152-57-4)

Guidance literature:

With naphthalene; sodium; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 ℃; for 0.5h;

DOI:10.1055/s-0031-1290137

Reference yield: 38.0%

N-(2-benzoylphenyl)-2-methoxyacetamide → 3-methoxy-4-phenyl-quinoline-2(1H)-one (6152-57-4)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1016/j.bmcl.2007.08.036

Reference yield:

4-hydroxy-3-methoxy-4-phenyl-3,4-dihydroquinoline-2(1H)-one → 3-methoxy-4-phenyl-quinoline-2(1H)-one (6152-57-4)

Guidance literature:

With palladium 10% on activated carbon; potassium carbonate; In methanol; at 50 ℃;

upstream raw materials:

methyl iodide

(E)-3-phenylpropenal

4-phenyl-1-tosyl-1,4-dihydroquinoline

4-phenyl-1-tosyl-1,2,3,4-tetrahydroquinoline-2,3-diol

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