thymidylyl-(3',5')-2'-deoxyguanosine

Base Information

• Chemical Name: thymidylyl-(3',5')-2'-deoxyguanosine
• CAS No.: 4251-20-1
• Molecular Formula: C₂₀H₂₆N₇O₁₁P
• Molecular Weight: 571.44
• Mol file: 4251-20-1.mol

Synonyms:Thymidylyl-(3',5')-2'-deoxyguanosine;d(Tpg);Thymidylyl phosphate deoxyguanosine;Guanosine,thymidylyl-(3'-5')-2'-deoxy;

Chemical Property of thymidylyl-(3',5')-2'-deoxyguanosine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 270.19000
• Density: 2.07g/cm³
• LogP: -1.04940

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of thymidylyl-(3',5')-2'-deoxyguanosine

There total 3 articles about thymidylyl-(3',5')-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphoric acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-5-(2,4-dioxo-5-phenylsulfanylmethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester → Thymidynyl-(3'->5')-2'-deoxyguanosine (4251-20-1)

Guidance literature:

With water; UV-irradiation;

DOI:10.1021/ol005643y

Reference yield:

C50H49N10O13P → Phosphoric acid (2R,3S,5R)-5-(4-amino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (81539-53-9) + Thymidynyl-(3'->5')-2'-deoxyguanosine (4251-20-1)

Guidance literature:

With 2-pyridinealdoxime; ammonium hydroxide; acetic acid; N,N,N',N'-tetramethylguanidine; Yield given. Multistep reaction. Yields of byproduct given; 1.) 15 h at room temperature, then 3 h at 40 deg C, 2.) 15 min at room temperature. Variation of reagents, solvents, temperatures and times;

DOI:10.1016/S0040-4039(00)61903-2

Reference yield:

→ Thymidynyl-(3'->5')-2'-deoxyguanosine (4251-20-1)

Guidance literature:

Pyridinium-N,O^3'-Diacetyl-desoxyguanosin-5'-phosphat, 5'-O--thymidin, DCC in Py. u.DMF;

DOI:10.1021/ja00906a022

Downstream raw materials:

trans-5-bromo-6-hydroxy-5,6-dihydrothymidylyl-(3'-5')-2'-deoxyguanosine

Refernces

• 1、 Huynh-Dinh, T.,d'Estaintot, B. Langlois,Allard, P.,Igolen, J.. "SYNTHESE SIMPLIFIEE DE SONDES MIXTES AVEC DES TRIAZOLO-NUCLEOSIDES". . p. 431 - 434. Retrieved 2007/10/02.