2-FLUORO-4-METHYLANISOLE

Base Information

• Chemical Name: 2-FLUORO-4-METHYLANISOLE
• CAS No.: 399-55-3
• Molecular Formula: C8H9FO
• Molecular Weight: 140.157
• Hs Code.: 2909309090
• Mol file: 399-55-3.mol

Synonyms:Anisole,2-fluoro-4-methyl- (7CI);2-Fluoro-1-methoxy-4-methylbenzene;2-Fluoro-4-methylanisole;

Chemical Property of 2-FLUORO-4-METHYLANISOLE

Chemical Property:

• Vapor Pressure: 1.18mmHg at 25°C
• Refractive Index: 1.495
• Boiling Point: 181 °C at 760 mmHg
• Flash Point: 63 °C
• PSA: 9.23000
• Density: 1.046 g/cm³
• LogP: 2.14270

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-4-methylanisole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-4-METHYLANISOLE

There total 9 articles about 2-FLUORO-4-METHYLANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-methoxy-5-methyldiazonium tetrafluoroborate → 2-fluoro-1-methoxy-4-methylbenzene (399-55-3)

Guidance literature:

With boron trifluoride diethyl etherate; at 0 ℃; Irradiation;

DOI:10.1002/1099-0690(20021)2002:2<369::AID-EJOC369>3.0.CO;2-7

Reference yield: 60.0%

2-Methyl-4-fluoro-5-methoxyaniline (77153-73-2) → 2-fluoro-1-methoxy-4-methylbenzene (399-55-3)

Guidance literature:

With isopentyl nitrite; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jo00325a017

Reference yield: 39.0%

→ 2-fluoro-1-methoxy-4-methylbenzene (399-55-3)

Guidance literature:

upstream raw materials:

p-methylanizole

2-Methyl-4-fluoro-5-methoxyaniline

5-methoxy-o-toluidine

Downstream raw materials:

3-fluoro-p-anisaldehyde

3-fluoro-p-anisic acid

4-((Z)-3-fluoro-4-methoxy-benzylidene)-2-phenyl-4H-oxazol-5-one

3-amino-3-(3-fluoro-4-methoxy-phenyl)-propionic acid