5-Amino-2-fluoro-4-methylanisole

Base Information

• Chemical Name: 5-Amino-2-fluoro-4-methylanisole
• CAS No.: 77153-73-2
• Molecular Formula: C₈H₁₀FNO
• Molecular Weight: 155.172
• Hs Code.: 2909309090
• Mol file: 77153-73-2.mol

Synonyms:2-Methyl-4-fluoro-5-methoxyaniline

Chemical Property of 5-Amino-2-fluoro-4-methylanisole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-2-fluoro-4-methylanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Amino-2-fluoro-4-methylanisole

There total 2 articles about 5-Amino-2-fluoro-4-methylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Azido-4-methoxy-1-methyl-benzene → 2-Methyl-4-fluoro-5-methoxyaniline (77153-73-2)

Guidance literature:

With hydrogen fluoride; In hexane; dichloromethane; at 5 ℃; for 1h; Yield given;

DOI:10.1021/jo00325a017

Reference yield:

5-methoxy-o-toluidine (50868-72-9) → 2-Methyl-4-fluoro-5-methoxyaniline (77153-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 10percent HCl, NaNO₂, 2.) NaN₃ / 1.) CH₂Cl₂, Hexane, Water, 5 deg C, 20 min, 2.) below 5 deg C, 3 h

2: anhydrous HF / CH₂Cl₂; hexane / 1 h / 5 °C

With hydrogenchloride; sodium azide; hydrogen fluoride; sodium nitrite; In hexane; dichloromethane;

DOI:10.1021/jo00325a017

Reference yield: 60.0%

2-Methyl-4-fluoro-5-methoxyaniline (77153-73-2) → 2-fluoro-1-methoxy-4-methylbenzene (399-55-3)

Guidance literature:

With isopentyl nitrite; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jo00325a017

upstream raw materials:

5-methoxy-o-toluidine

Downstream raw materials:

2-fluoro-1-methoxy-4-methylbenzene