2-cyano-N-(2-nitrophenyl)acetamide

Base Information

• Chemical Name: 2-cyano-N-(2-nitrophenyl)acetamide
• CAS No.: 65372-22-7
• Molecular Formula: C9H7N3O3
• Molecular Weight: 205.173
• Hs Code.: 2926909090
• Mol file: 65372-22-7.mol

Synonyms:2-cyano-N-[2-(nitro)phenyl]acetamide;2-cyano-N-(2-methyl-6-nitro-phenyl)-acetamide;N-(2-nitrophenyl)-2-cyanoacetamide;Cyanessigsaeure-(2-nitro-anilid);N-<2-Cyan-acetyl>-2-nitro-anilin;Acetamide,2-cyano-N-(2-methyl-6-nitrophenyl);

Chemical Property of 2-cyano-N-(2-nitrophenyl)acetamide

Chemical Property:

• PSA: 98.71000
• LogP: 2.04318

Purity/Quality:

98%min ^*data from raw suppliers

2-Cyano-N-(2-nitrophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-cyano-N-(2-nitrophenyl)acetamide

There total 3 articles about 2-cyano-N-(2-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyanoacetic acid (372-09-8) + 2-nitro-aniline (88-74-4) → 2-cyano-N-[2-(nitro)phenyl]acetamide (65372-22-7)

Guidance literature:

cyanoacetic acid; With phosphorus pentachloride; In dichloromethane; for 0.5h; Reflux;

2-nitro-aniline; In dichloromethane; for 2h; Reflux;

DOI:10.1021/jm3002845

Reference yield:

2-nitro-aniline (88-74-4) + ethyl 2-cyanoacetate (105-56-6) → 2-cyano-N-[2-(nitro)phenyl]acetamide (65372-22-7)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.ejmech.2015.10.046

Reference yield:

→ 2-cyano-N-[2-(nitro)phenyl]acetamide (65372-22-7)

Guidance literature:

Cyan-acetylchlorid (aus Cyan-essigsaeure u. Phosphor(V)-chlorid in Aether), 2-Nitro-anilin / Δ;

DOI:10.1039/jr9640002666

upstream raw materials:

cyanoacetic acid

2-nitro-aniline

ethyl 2-cyanoacetate

Downstream raw materials:

3-amino-3-(hydroxyimino)-N-[2-(nitro)phenyl]propanamide

ethyl 2-amino-5-cyano-1-(2-nitrophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylate

6-amino-1-(2-nitrophenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

2-(2-chloroacetyl)amino-N-(2-nitrophenyl)thiophene-3-carboxamide

Refernces

• 1、 Shaik, Jeelan Basha,Palaka, Bhagath Kumar,Penumala, Mohan,Kotapati, Kasi Viswanath,Devineni, Subba Rao,Eadlapalli, Siddhartha,Darla, M. Manidhar,Ampasala, Dinakara Rao,Vadde, Ramakrishna,Amooru, G. Damu. "Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents". . p. 219 - 232. Retrieved 2015/11/24.
• 2、 Walser,Flynn,Mason. "Pentacyclic triazolodiazepines as PAF-antagonists". . p. 1121 - 1125. Retrieved 2007/10/02.