Phenol, 4-chloro-2-(1-methylethenyl)-

Base Information

• Chemical Name: Phenol, 4-chloro-2-(1-methylethenyl)-
• CAS No.: 65490-18-8
• Molecular Formula: C9H9ClO
• Molecular Weight: 168.623
• Mol file: 65490-18-8.mol

Synonyms:

Chemical Property of Phenol, 4-chloro-2-(1-methylethenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 4-chloro-2-(1-methylethenyl)-

There total 2 articles about Phenol, 4-chloro-2-(1-methylethenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-chloro-2-hydroxyacetophenone (1450-74-4) + Methyltriphenylphosphonium bromide (1779-49-3) → 4-chloro-2-(prop-1-en-2-yl)phenol (65490-18-8)

Guidance literature:

Methyltriphenylphosphonium bromide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere; Schlenk technique;

5-chloro-2-hydroxyacetophenone; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201412148

Reference yield:

→ 4-chloro-2-(prop-1-en-2-yl)phenol (65490-18-8)

Guidance literature:

6-Chlor-4-methylcoumarin (1f), NaOH, Ethandiol;

Reference yield: 90.0%

4-chloro-2-(prop-1-en-2-yl)phenol (65490-18-8) + 4-methyl-1-((triisopropylsilyl)ethynyl)-1λ3-benzo[d][1,2]iodoxol-3(1H)-one (1377861-42-1) → (Z)-4-chloro-2-(5-(triisopropylsilyl)pent-2-en-4-yn-2-yl)phenol

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 2h; stereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201412148

upstream raw materials:

5-chloro-2-hydroxyacetophenone

Methyltriphenylphosphonium bromide

Downstream raw materials:

Acetic acid 4-chloro-2-isopropenyl-phenyl ester

Acetic acid (E)-2-(5-chloro-2-hydroxy-phenyl)-propenyl ester

Acetic acid 4-chloro-2-(2-methyl-oxiranyl)-phenyl ester