3,5-Dichloro-DL-Phenylalanine

Base Information

• Chemical Name: 3,5-Dichloro-DL-Phenylalanine
• CAS No.: 93930-25-7
• Molecular Formula: C₉H₉Cl₂NO₂
• Molecular Weight: 234.082
• Mol file: 93930-25-7.mol

Synonyms:3,5-Dichloro-DL-Phenylalanine;

Chemical Property of 3,5-Dichloro-DL-Phenylalanine

Chemical Property:

• Vapor Pressure: 4.55E-06mmHg at 25°C
• Melting Point: 229-230 °C
• Boiling Point: 368.1°Cat760mmHg
• Flash Point: 176.4°C
• PSA: 63.32000
• Density: 1.45g/cm³
• LogP: 2.64810

Purity/Quality:

98%min ^*data from raw suppliers

3,5-DICHLORO-DL-PHENYLALANINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dichloro-DL-Phenylalanine

There total 2 articles about 3,5-Dichloro-DL-Phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3,5-dichlorophenyl)-2-propenoic acid (20595-53-3,90418-21-6) → C9H9Cl2NO2 (93930-25-7,13990-04-0)

Guidance literature:

With ammonium hydroxide; carbon dioxide; In dimethyl sulfoxide; at 37 ℃; for 12h; pH=10; Reagent/catalyst; stereoselective reaction; Enzymatic reaction;

DOI:10.1016/j.tet.2015.12.063

Reference yield:

3,5-dichlorobenzaldehyde (10203-08-4) → C9H9Cl2NO2 (93930-25-7,13990-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dimethyl sulfoxide / 0.33 h / 60 °C / Microwave irradiation; Sealed tube

2: ammonium hydroxide; carbon dioxide / dimethyl sulfoxide / 12 h / 37 °C / pH 10 / Enzymatic reaction

With piperidine; ammonium hydroxide; carbon dioxide; In dimethyl sulfoxide; 1: |Knoevenagel Condensation;

DOI:10.1016/j.tet.2015.12.063

upstream raw materials:

3-(3,5-dichlorophenyl)-2-propenoic acid

3,5-dichlorobenzaldehyde

Refernces