Diethyl (1-hydroxy-2-oxo-1,2-diphenylethyl)phosphonate

Base Information

Chemical Name:Diethyl (1-hydroxy-2-oxo-1,2-diphenylethyl)phosphonate
CAS No.:65601-38-9
Molecular Formula:C18H21O5P
Molecular Weight:348.336
Hs Code.:
DSSTox Substance ID:DTXSID30500684

Synonyms:65601-38-9;Diethyl (1-hydroxy-2-oxo-1,2-diphenylethyl)phosphonate;DTXSID30500684

Suppliers and Price of Diethyl (1-hydroxy-2-oxo-1,2-diphenylethyl)phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Diethyl (1-hydroxy-2-oxo-1,2-diphenylethyl)phosphonate

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:348.11266076
Heavy Atom Count:24
Complexity:444

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(C(C1=CC=CC=C1)(C(=O)C2=CC=CC=C2)O)OCC

Technology Process of Diethyl (1-hydroxy-2-oxo-1,2-diphenylethyl)phosphonate

There total 4 articles about Diethyl (1-hydroxy-2-oxo-1,2-diphenylethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 71292-75-6
diethyl α-benzoyl-α-<(trimethylsilyl)oxy>benzylphosphonate

: 65601-38-9
diethyl α-benzoyl-α-hydroxybenzylphosphonate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; water; for 2h; Heating;
DOI:10.1246/bcsj.55.218

Reference yield: 55.0%

: 762-04-9
phosphonic acid diethyl ester

: 134-81-6
benzil

: 65601-38-9
diethyl α-benzoyl-α-hydroxybenzylphosphonate

Guidance literature:: With n-butyllithium; In neat (no solvent); at 10 ℃; for 0.0833333h; Catalytic behavior; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol5030713

Reference yield:

: 31675-43-1
diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate

: 65601-38-9
diethyl α-benzoyl-α-hydroxybenzylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 0.5 h, 2.) THF, 0.5 h

2: 66 percent / p-toluenesulfonic acid monohydrate / methanol; H₂O / 2 h / Heating

With toluene-4-sulfonic acid; lithium diisopropyl amide; In methanol; water;
DOI:10.1246/bcsj.55.218