4-TERT-BUTYLBENZENESULFONOHYDRAZIDE

Base Information

• Chemical Name: 4-TERT-BUTYLBENZENESULFONOHYDRAZIDE
• CAS No.: 65604-75-3
• Molecular Formula: C10H16N2O2S
• Molecular Weight: 228.315
• Mol file: 65604-75-3.mol

Synonyms:p-tert-butylbenzenesulfonylhydrazide;p-tert-butylbenzenesulfonyl hydrazide;4-(tert-butyl)benzenesulfonohydrazide;p-tertbutylphenylsulfonyl hydrazide;

Chemical Property of 4-TERT-BUTYLBENZENESULFONOHYDRAZIDE

Chemical Property:

• Melting Point: 92 - 94 °C
• PSA: 80.57000
• LogP: 3.30810

Purity/Quality:

98%min ^*data from raw suppliers

4-tert-Butylbenzenesulfonohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-TERT-BUTYLBENZENESULFONOHYDRAZIDE

There total 1 articles about 4-TERT-BUTYLBENZENESULFONOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-tert-butylbenzenesulfonyl chloride (15084-51-2) → 4-(tert-butyl)benzenesulfonyl hydrazide (65604-75-3)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.jfluchem.2013.01.033

Reference yield: 94.0%

N,3-diphenyl-1-tosyl-1H-pyrazol-5-amine + 4-(tert-butyl)benzenesulfonyl hydrazide (65604-75-3) → 4-{[4-(tert-butyl)phenyl]thio}-N,5-diphenyl-1H-pyrazol-3-amine

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In ethanol; at 80 ℃; for 12h; Sealed tube;

DOI:10.1055/a-1592-6394

Reference yield: 91.0%

Dimethyl phosphite (868-85-9) + 4-(tert-butyl)benzenesulfonyl hydrazide (65604-75-3) → 1-(tert-butyl)-4-(methylsulfonyl)benzene (22796-14-1)

Guidance literature:

With sodium iodide; In 1,2-dimethoxyethane; water; at 65 ℃; for 8h;

DOI:10.1055/a-1581-2271

upstream raw materials:

4-tert-butylbenzenesulfonyl chloride

Downstream raw materials:

2-(4-(tert-butyl)phenyl)benzo[d]oxazole

2-((4-(tert-butyl)phenyl)sulfonyl)-N-(1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl)hydrazine-1-carboxamide

4-(4-tert-butylphenyl)-4-phenylbutan-2-one

Refernces

• 1、 Bourbon, Paul,Appert, Emeline,Martin-Mingot, Agnès,Michelet, Bastien,Thibaudeau, Sébastien. "Complementary Site-Selective Sulfonylation of Aromatic Amines by Superacid Activation". supporting information. p. 4115 - 4120. Retrieved 2021/06/21.
• 2、 Chen, Kai,Duan, Xin-Yu,Gao, Jie,Guan, Jian-Ping,Liu, Fang,Xiang, Hao-Yue,Xiao, Jun-An,Yang, Hua,Ye, Zhi-Peng. "Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols". supporting information. p. 8969 - 8972. Retrieved 2021/09/10.