- Chemical Name:Dimethoxyphosphinylradical
- CAS No.:868-85-9
- Molecular Formula:C2H7O3P
- Molecular Weight:110.05
- Hs Code.:29209013
- Nikkaji Number:J1.739F,J1.368.989J
- Mol file:868-85-9.mol
Synonyms:Phosphonic acid dimethyl;Dimethoxyphosphinylradical
Synonyms:Phosphonic acid dimethyl;Dimethoxyphosphinylradical
99.9% *data from raw suppliers
Dimethyl phosphite 98% *data from reagent suppliers
There total 81 articles about Dimethoxyphosphinylradical which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 90.0%
Reference yield: 72.0%
Reference yield: 63.0%
The research focuses on the highly efficient synthesis of quaternary α-hydroxy phosphonates through Lewis acid-catalyzed hydrophosphonylation of ketones. The study introduces a novel method that utilizes a Lewis acid catalyst, specifically Ti(O-i-Pr)4, to achieve high yields (up to 98%) of quaternary α-hydroxy phosphonates, which are valuable compounds in pharmaceutical chemistry. The experiments involved the reaction of various ketones with dimethyl phosphite in the presence of the Lewis acid catalyst. The reaction conditions, such as concentration and temperature, were optimized to improve reactivity and yield. The substrate scope was explored under solvent-free conditions, and the products were purified by column chromatography on silica gel. The study also achieved the first catalytic enantioselective hydrophosphonylation of an unactivated ketone using a tridentate Schiff base-titanium complex, although with moderate enantioselectivity. The research was supported by the National Natural Science Foundation of China and the Ministry of Education, and NMR analysis was conducted at Sichuan University Analytical & Testing Center.