N-(1,3-benzodioxol-5-ylmethyl)benzamide

Base Information

• Chemical Name: N-(1,3-benzodioxol-5-ylmethyl)benzamide
• CAS No.: 65609-38-3
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.273
• DSSTox Substance ID: DTXSID801330670
• Nikkaji Number: J1.657.260H
• ChEMBL ID: CHEMBL1313259
• Mol file: 65609-38-3.mol

Synonyms:N-(1,3-benzodioxol-5-ylmethyl)benzamide;65609-38-3;N-benzoylpiperonylamine;Oprea1_441370;MLS001005209;SCHEMBL4925396;CHEMBL1313259;ZHSOGONPVBHPEW-UHFFFAOYSA-N;DTXSID801330670;HMS2753O22;STK049535;AKOS001293502;SMR000378076;N-(1,3-Benzodioxole-5-ylmethyl)benzamide;Z27695360

Chemical Property of N-(1,3-benzodioxol-5-ylmethyl)benzamide

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 255.08954328
• Heavy Atom Count: 19
• Complexity: 315

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1OC2=C(O1)C=C(C=C2)CNC(=O)C3=CC=CC=C3

Technology Process of N-(1,3-benzodioxol-5-ylmethyl)benzamide

There total 12 articles about N-(1,3-benzodioxol-5-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

piperonol (495-76-1) + benzamide (55-21-0,27208-38-4) → N-(benzo[d][1,3]dioxol-5-ylmethyl)benzamide (65609-38-3)

Guidance literature:

With palladium diacetate; potassium carbonate; In toluene; at 150 ℃; for 24h;

DOI:10.1055/s-0030-1260238

Reference yield: 94.0%

1,3-benzodioxol-5-ylmethyl amine (2620-50-0) + vinyl benzoate (769-78-8,24991-32-0) → N-(benzo[d][1,3]dioxol-5-ylmethyl)benzamide (65609-38-3)

Guidance literature:

In neat (no solvent); at 20 ℃; for 24h; Green chemistry;

DOI:10.1080/00397911.2014.898072

Reference yield: 93.0%

1,3-benzodioxol-5-ylmethyl amine (2620-50-0) + tert-butyl benzoyl(quinolin-8-yl)carbamate → N-(benzo[d][1,3]dioxol-5-ylmethyl)benzamide (65609-38-3)

Guidance literature:

In toluene; at 60 ℃; for 7h; Sealed tube;

DOI:10.1021/acs.joc.8b00174

upstream raw materials:

1,3-benzodioxol-5-ylmethyl amine

benzoyl chloride

piperonal-(Z)-oxime

piperonol

Downstream raw materials:

N-(2-azido-benzoyl)-N-benzo[1,3]dioxol-5-ylmethyl-benzamide

N-(2-azido-3-methyl-benzoyl)-N-benzo[1,3]dioxol-5-ylmethyl-benzamide

N-(2-azido-5-iodo-benzoyl)-N-benzo[1,3]dioxol-5-ylmethyl-benzamide