Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-1-methyl-2-phenyl-

Base Information

Chemical Name:Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-1-methyl-2-phenyl-
CAS No.:61001-41-0
Molecular Formula:C₁₈H₁₆N₂
Molecular Weight:260.338
Hs Code.:
UNII:2QJA338S2T
DSSTox Substance ID:DTXSID00209879
Wikidata:Q83084342

Synonyms:BRN 0661965;Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-1-methyl-2-phenyl-;61001-41-0;5,6-Dihydro-1-methyl-2-phenylpyrazolo(5,1-a)isoquinoline;1-Methyl-2-phenyl-5,6-dihydro-pyrazolo(5,1-a)isoquinoline;5-23-09-00428 (Beilstein Handbook Reference);5,6-Dihydro-1-methyl-2-phenylpyrazolo[5,1-a]isoquinoline;Pyrazolo[5,1-a]isoquinoline, 5,6-dihydro-1-methyl-2-phenyl-;2QJA338S2T;DTXSID00209879;LS-128982

Suppliers and Price of Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-1-methyl-2-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-1-methyl-2-phenyl-

Chemical Property:

Vapor Pressure:7.12E-08mmHg at 25°C
Boiling Point:450.3°Cat760mmHg
Flash Point:226.1°C
Density:1.16g/cm³
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:260.131348519
Heavy Atom Count:20
Complexity:336

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C3=CC=CC=C3CCN2N=C1C4=CC=CC=C4

Technology Process of Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-1-methyl-2-phenyl-

There total 8 articles about Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-1-methyl-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39113-01-4
2-amino-3,4-dihydro-1(2H)-isoquinolinone

: 61001-41-0
1-methyl-2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 20.2 g / p-toluenesulfonic acid / benzene / 1 h / Heating

2: 18.3 g / potassium t-butoxide / 2-methyl-propan-2-ol / 5 h / Heating

3: 76 percent / potassium bicarbonate / N,N-dimethyl-acetamide / 15 h / Ambient temperature

4: 72 percent / LiAlH₄ / tetrahydrofuran / 1.) room temp., 4 h; 2.) reflux, 1 h

5: 4 g / hydrogen bromide / acetic acid / 21 h / 60 °C

6: 98percent lithium hydride, LiAlH₄ / tetrahydrofuran / 1.) room temp., 10 h; 2.) 60 deg C, 1 h

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen bromide; lithium hydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl acetamide; acetic acid; tert-butyl alcohol; benzene;

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 61001-41-0
1-methyl-2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 20.2 g / p-toluenesulfonic acid / benzene / 1 h / Heating

2: 18.3 g / potassium t-butoxide / 2-methyl-propan-2-ol / 5 h / Heating

3: 76 percent / potassium bicarbonate / N,N-dimethyl-acetamide / 15 h / Ambient temperature

4: 72 percent / LiAlH₄ / tetrahydrofuran / 1.) room temp., 4 h; 2.) reflux, 1 h

5: 4 g / hydrogen bromide / acetic acid / 21 h / 60 °C

6: 98percent lithium hydride, LiAlH₄ / tetrahydrofuran / 1.) room temp., 10 h; 2.) 60 deg C, 1 h

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen bromide; lithium hydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl acetamide; acetic acid; tert-butyl alcohol; benzene;

Reference yield:

: 61001-51-2
1-bromomethyl-2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline hydrobromide

: 61001-41-0
1-methyl-2-phenyl-5,6-dihydro-pyrazolo<5,1-a>isoquinoline

Guidance literature:: With lithium aluminium tetrahydride; lithium hydride; In tetrahydrofuran; Yield given; 1.) room temp., 10 h; 2.) 60 deg C, 1 h;