METHYL 3-AMINO-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE

Base Information

Chemical Name:METHYL 3-AMINO-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE
CAS No.:65639-61-4
Molecular Formula:C13H19N3O2
Molecular Weight:249.313
Hs Code.:

Synonyms:3-amino-4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester;Methyl 3-amino-4-(4-methylpiperazin-1-yl) benzoate;

Suppliers and Price of METHYL 3-AMINO-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of METHYL 3-AMINO-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE

Chemical Property:

Melting Point:172 - 175 °C
PSA：58.80000
LogP:1.39130

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of METHYL 3-AMINO-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE

There total 5 articles about METHYL 3-AMINO-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

: 65715-48-2
methyl 4-(4-methylpiperazin-1-yl)-3-nitrobenzoate

: 65639-61-4
methyl 3-amino-4-(4-methylpiperazin-1-yl) benzoate

Guidance literature:: With tin(II) chloride dihdyrate; In ethyl acetate; for 8h; Reflux;
DOI:10.1016/j.bmc.2016.09.073

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 65639-61-4
methyl 3-amino-4-(4-methylpiperazin-1-yl) benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 6 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4: tin(II) chloride dihdyrate / ethyl acetate / 8 h / Reflux

With thionyl chloride; tin(II) chloride dihdyrate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.09.073

Reference yield:

: 400-94-2
4-fluoro-3-nitrobenzoyl chloride

: 65639-61-4
methyl 3-amino-4-(4-methylpiperazin-1-yl) benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3: tin(II) chloride dihdyrate / ethyl acetate / 8 h / Reflux

With tin(II) chloride dihdyrate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.09.073