2-Fluorophenylhydrazine

Base Information

• Chemical Name: 2-Fluorophenylhydrazine
• CAS No.: 2368-80-1
• Molecular Formula: C6H7FN2
• Molecular Weight: 126.133
• Hs Code.: 2928000090
• European Community (EC) Number: 874-609-2
• DSSTox Substance ID: DTXSID4062353
• Nikkaji Number: J5.196I
• Wikidata: Q72476002
• Mol file: 2368-80-1.mol

Synonyms:2-Fluorophenylhydrazine;(2-fluorophenyl)hydrazine;2368-80-1;Hydrazine, (2-fluorophenyl)-;1-(2-Fluorophenyl)hydrazine;2-fluorophenyl hydrazine;EINECS 220-885-9;o-Fluorophenylhydrazine;RHODINYLPROPIONATE;2-fluoro-phenylhydrazine;SCHEMBL7022;(2-Fluoro-phenyl)-hydrazine;Hydrazine, (2-fluorophenyl);1-(2-Fluorophenyl)hydrazine #;DTXSID4062353;BBL027973;CK1203;MFCD00041260;STK503650;AKOS005171620;NSC 158012;DS-13889;BB 0249784;FT-0600893;EN300-24493

Chemical Property of 2-Fluorophenylhydrazine

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.182mmHg at 25°C
• Melting Point: 47°C
• Refractive Index: 1.609
• Boiling Point: 211.5 °C at 760 mmHg
• PKA: 4.73±0.10(Predicted)
• Flash Point: 81.7 °C
• PSA: 38.05000
• Density: 1.257 g/cm³
• LogP: 1.88460
• Storage Temp.: Keep Cold
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 126.05932639
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

2-Fluorophenylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NN)F
• General Description: 2-Fluorophenylhydrazine is a chemical compound with the molecular formula C6H7FN2, characterized by the presence of a fluorine atom at the ortho position of the phenyl ring attached to a hydrazine group. It is commonly referred to by synonyms such as Hydrazine, (o-fluorophenyl)-, (o-Fluorophenyl)hydrazine, or 1-(2-Fluorophenyl)hydrazine. 2-Fluorophenylhydrazine is typically used as an intermediate in organic synthesis, particularly in the preparation of heterocyclic compounds or pharmaceuticals, due to its reactive hydrazine moiety and the influence of the fluorine substituent on its electronic properties. Its applications may include the synthesis of dyes, agrochemicals, or biologically active molecules, though specific uses depend on the context of the synthesis.

Technology Process of 2-Fluorophenylhydrazine

There total 5 articles about 2-Fluorophenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-fluorobenzenediazonium tetrafluoroborate (446-46-8) → 2-fluorophenylhydrazine (2368-80-1)

Guidance literature:

With nickel dichloride; zinc; In tetrahydrofuran;

DOI:10.1039/a905588f

Reference yield: 74.0%

2-Fluoroaniline (348-54-9) + butan-1-ol (71-36-3) → 2-fluorophenylhydrazine (2368-80-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium hydrogen sulfate; sodium nitrite;

Reference yield:

2-Fluoroaniline (348-54-9) → 2-fluorophenylhydrazine (2368-80-1)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; sodium nitrite; Multistep reaction; 1.) H₂O, 0 deg C, 2.) H₂O, RT, 1 h;

DOI:10.1021/jm00113a031

upstream raw materials:

2-Fluoroaniline

2-fluorobenzenediazonium tetrafluoroborate

butan-1-ol

1-chloro-2-fluorobenzene

Downstream raw materials:

D-arabino-[2]hexosulose-bis-(2-fluoro-phenylhydrazone)

5-amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile

1-[1-(2-fluoro-phenyl)-5-methyl-1H-pyrazol-4-yl]-ethanone

[(2-Fluoro-phenyl)-hydrazono]-(1H-indol-3-yl)-acetic acid ethyl ester

Refernces

Fischer indole synthesis in water: Simple, efficient preparation of naltrindole, naltriben and analogs

10.1039/b920864j

The research presents an environmentally friendly method for synthesizing naltrindole (NTI), naltriben (NTB), and their analogs using Fischer indole synthesis under mildly acidic, purely aqueous conditions. The study explores the preparation of these compounds, which are valuable tools for opioid receptor pharmacology studies, using hydrochloride salts of naltrexone and various phenylhydrazines in boiling water, achieving good to excellent yields and high purities without the need for organic solvents or harsh acids. The chemicals that played a crucial role in this research include naltrexone hydrochloride (NTX·HCl), phenylhydrazine hydrochloride, and other substituted phenylhydrazines such as 1-methyl-1-phenylhydrazine, o-chlorophenylhydrazine, o-fluorophenylhydrazine, and o-nitrophenylhydrazine. The study also utilized dilute hydrochloric acid (HCl) to facilitate the synthesis, and in some cases, sulfuric acid (H?SO?) for comparison. The products were obtained through simple filtration or centrifugation, highlighting the simplicity and efficiency of the aqueous Fischer synthesis method.

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