5-oxo-L-proline hydrazide

Base Information

• Chemical Name: 5-oxo-L-proline hydrazide
• CAS No.: 934-06-5
• Molecular Formula: C5H9 N3 O2
• Molecular Weight: 143.145
• Hs Code.: 2933790090
• European Community (EC) Number: 213-278-5
• DSSTox Substance ID: DTXSID601312230
• Nikkaji Number: J298.521G
• ChEMBL ID: CHEMBL4238859
• Mol file: 934-06-5.mol

Synonyms:5-oxo-L-proline hydrazide;934-06-5;C5H9N3O2;SCHEMBL2827980;CHEMBL4238859;DTXSID601312230;AKOS006352121

Chemical Property of 5-oxo-L-proline hydrazide

Chemical Property:

• Vapor Pressure: 1.93E-11mmHg at 25°C
• Boiling Point: 533°Cat760mmHg
• Flash Point: 276.2°C
• PSA: 91.20000
• Density: 1.319g/cm³
• LogP: 0.07140
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 143.069476538
• Heavy Atom Count: 10
• Complexity: 168

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)NC1C(=O)NN
• Isomeric SMILES: C1CC(=O)N[C@@H]1C(=O)NN

Technology Process of 5-oxo-L-proline hydrazide

There total 3 articles about 5-oxo-L-proline hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl (S)-pyroglutamate (4931-66-2) → (S)-5-oxopyrrolidine-2-carbohydrazide (934-06-5)

Guidance literature:

With hydrazine; In water; at 20 ℃;

DOI:10.1016/j.bmc.2018.07.041

Reference yield:

→ (S)-5-oxopyrrolidine-2-carbohydrazide (934-06-5)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1021/ja01157a021

Reference yield:

L-Pyroglutamic acid (98-79-3) → (S)-5-oxopyrrolidine-2-carbohydrazide (934-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; chloroform / Molecular sieve; Reflux

2: hydrazine hydrate / 24 h / 20 °C

With hydrazine hydrate; In methanol; chloroform;

DOI:10.1016/j.bmcl.2020.127220

upstream raw materials:

methyl (S)-pyroglutamate

L-Pyroglutamic acid

Downstream raw materials:

5-oxo-L-proline-(1-methyl-2-phenyl-ethylLiDenehydrazide)