Cyclobutoic

Base Information

• Chemical Name: Cyclobutoic
• CAS No.: 17692-20-5
• Molecular Formula: C10H18 O3
• Molecular Weight: 0
• Hs Code.: 2918199090
• Mol file: 17692-20-5.mol

Synonyms:Cyclohexanehydracrylicacid, b-methyl- (8CI);3-Cyclohexyl-3-hydroxybutyric acid; Adrilyl; Cyclobutoic acid; b-Hydroxy-b-methylcyclohexanepropionic acid

Chemical Property of Cyclobutoic

Chemical Property:

• Vapor Pressure: 1.02E-05mmHg at 25°C
• Boiling Point: 332.8°Cat760mmHg
• Flash Point: 169.3°C
• PSA: 57.53000
• Density: 1.129g/cm³
• LogP: 1.79240
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Cyclohexyl-3-hydroxybutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutoic

There total 3 articles about Cyclobutoic which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 3-hydroxy-3-cyclohexylbutyrate (28811-84-9) → 3-hydroxy-3-cyclohexylbutyric acid (17692-20-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1021/jm00366a021

Reference yield: 53.0%

acetic acid (64-19-7,77671-22-8) + Cyclohexyl methyl ketone (823-76-7) → 3-hydroxy-3-cyclohexylbutyric acid (17692-20-5)

Guidance literature:

acetic acid; With n-butyllithium; diethylamine; In tetrahydrofuran; at -78 - 0 ℃;

Cyclohexyl methyl ketone; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200390195

Reference yield:

Cyclohexyl methyl ketone (823-76-7) → 3-hydroxy-3-cyclohexylbutyric acid (17692-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / zinc / benzene / 2 h / Heating

2: 92 percent / KOH / aq. ethanol / 3 h / Heating

With potassium hydroxide; zinc; In ethanol; benzene;

DOI:10.1021/jm00366a021

upstream raw materials:

ethyl 3-hydroxy-3-cyclohexylbutyrate

acetic acid

Cyclohexyl methyl ketone

Refernces

• 1、 Carganico, Germano,Cozzi, Paolo,Orsini, Gaetano. "Synthesis of 3-Hydroxy-3-cyclohexylbutyric Acid Derivatives. 2. Cyclic Analogues of Mevalonic Acid". . p. 1767 - 1769. Retrieved 2007/10/02.