1H-1,2,4-Triazole-3-carboxamide, 5-(aminomethyl)-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-, hydrobromide

Base Information

• Chemical Name: 1H-1,2,4-Triazole-3-carboxamide, 5-(aminomethyl)-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-, hydrobromide
• CAS No.: 65699-26-5
• Molecular Formula: C19H17Cl2N5O2.xBrH
• Molecular Weight: 499.194
• Mol file: 65699-26-5.mol

Synonyms:

Chemical Property of 1H-1,2,4-Triazole-3-carboxamide, 5-(aminomethyl)-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-, hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-1,2,4-Triazole-3-carboxamide, 5-(aminomethyl)-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-, hydrobromide

There total 7 articles about 1H-1,2,4-Triazole-3-carboxamide, 5-(aminomethyl)-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-, hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid hydrobromide (37348-16-6) + 2',5-dichloro-2-(3-dimethylcarbamoyl-5-benzyloxycarbonylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone (65699-21-0) → 2',5-dichloro-2-(3-dimethylcarbamoyl-5-aminomethyl-1H-1,2,4-triazol-1-yl)benzophenone hydrobromide (65699-26-5)

Guidance literature:

Reference yield:

N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide (65698-99-9) → 2',5-dichloro-2-(3-dimethylcarbamoyl-5-aminomethyl-1H-1,2,4-triazol-1-yl)benzophenone hydrobromide (65699-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / K₂CO₃ / tetrahydrofuran; dimethylformamide / Ambient temperature; overnight

2: 30percent HBr/acetic acid / 2 h / Ambient temperature

With hydrogen bromide; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570190621

Reference yield:

C17H15Cl2N3O3 (65698-98-8) → 2',5-dichloro-2-(3-dimethylcarbamoyl-5-aminomethyl-1H-1,2,4-triazol-1-yl)benzophenone hydrobromide (65699-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / methanol / 96 h / Ambient temperature

2: 47 percent / K₂CO₃ / tetrahydrofuran; dimethylformamide / Ambient temperature; overnight

3: 30percent HBr/acetic acid / 2 h / Ambient temperature

With hydrogen bromide; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570190621

upstream raw materials:

8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[1,5-a][1,4]diazepine-2-carboxylic acid dimethylamide

2',5-dichloro-2-(3-dimethylcarbamoyl-5-benzyloxycarbonylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone

N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide

C₁₇H₁₅Cl₂N₃O₃

Downstream raw materials:

1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

5-(benzoylamino-methyl)-1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

5-(acetylamino-methyl)-1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-(isobutyrylamino-methyl)-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide