Carbamic acid, [[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1H -1,2,4-triazol-5-yl]methyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1H -1,2,4-triazol-5-yl]methyl]-, phenylmethyl ester
• CAS No.: 65699-21-0
• Molecular Formula: C₂₇H₂₃Cl₂N₅O₄
• Molecular Weight: 552.417
• Mol file: 65699-21-0.mol

Synonyms:

Chemical Property of Carbamic acid, [[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1H -1,2,4-triazol-5-yl]methyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1H -1,2,4-triazol-5-yl]methyl]-, phenylmethyl ester

There total 6 articles about Carbamic acid, [[1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-[(dimethylamino)carbonyl]-1H -1,2,4-triazol-5-yl]methyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide (65698-99-9) + N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) → 2',5-dichloro-2-(3-dimethylcarbamoyl-5-benzyloxycarbonylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone (65699-21-0)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; Ambient temperature; overnight;

DOI:10.1002/jhet.5570190621

Reference yield:

C17H15Cl2N3O3 (65698-98-8) → 2',5-dichloro-2-(3-dimethylcarbamoyl-5-benzyloxycarbonylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone (65699-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / methanol / 96 h / Ambient temperature

2: 47 percent / K₂CO₃ / tetrahydrofuran; dimethylformamide / Ambient temperature; overnight

With potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570190621

Reference yield:

N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide (85815-52-7) → 2',5-dichloro-2-(3-dimethylcarbamoyl-5-benzyloxycarbonylaminomethyl-1H-1,2,4-triazol-1-yl)benzophenone (65699-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.8 percent / aq. ammonia (28percent) / ethyl acetate / 2 h / Ambient temperature

2: 47 percent / K₂CO₃ / tetrahydrofuran; dimethylformamide / Ambient temperature; overnight

With ammonium hydroxide; potassium carbonate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570190621

upstream raw materials:

N,N-dimethyl 2-amino-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetamide

N-(benzyloxycarbonyl)glycyl chloride

C₁₇H₁₅Cl₂N₃O₃

N,N-dimethyl 2-chloro-2-(2-(2-chlorobenzoyl)-5-chlorophenylazo)acetoacetamide

Downstream raw materials:

2',5-dichloro-2-(3-dimethylcarbamoyl-5-aminomethyl-1H-1,2,4-triazol-1-yl)benzophenone hydrobromide

1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-[(2-pyrrolidin-1-yl-acetylamino)-methyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

5-(benzoylamino-methyl)-1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide

1-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[(N-methyl-glycyl)-amino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide