2-(3,4-DIMETHOXY-PHENYL)-PIPERAZINE

Base Information

• Chemical Name: 2-(3,4-DIMETHOXY-PHENYL)-PIPERAZINE
• CAS No.: 65709-39-9
• Molecular Formula: C12H18N2O2
• Molecular Weight: 222.287
• Hs Code.: 2933599090
• Mol file: 65709-39-9.mol

Synonyms:

Chemical Property of 2-(3,4-DIMETHOXY-PHENYL)-PIPERAZINE

Chemical Property:

• Vapor Pressure: 3.48E-07mmHg at 25°C
• Boiling Point: 411.9oC at 760 mmHg
• Flash Point: 202.9oC
• PSA: 42.52000
• LogP: 1.59530

Purity/Quality:

98%min ^*data from raw suppliers

2-(3,4-DIMETHOXY-PHENYL)-PIPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,4-DIMETHOXY-PHENYL)-PIPERAZINE

There total 5 articles about 2-(3,4-DIMETHOXY-PHENYL)-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C26H30N2O2 (1421005-05-1) → 2-(3,4-dimethoxy-phenyl)-piperazine (65709-39-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 4h;

DOI:10.1016/j.tetlet.2012.11.110

Reference yield: 22.0%

3',4'-dimethoxyphenylglyoxal (15462-03-0) + ethylenediamine (107-15-3,85404-18-8) → 2-(3,4-dimethoxy-phenyl)-piperazine (65709-39-9)

Guidance literature:

3',4'-dimethoxyphenylglyoxal; ethylenediamine; In tetrahydrofuran; methanol; at 0 ℃;

With sodium tetrahydroborate; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2017.06.078

Reference yield:

3,4-dimethoxystyrene (6380-23-0) → 2-(3,4-dimethoxy-phenyl)-piperazine (65709-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: HgO*2HBF₄ / tetrahydrofuran / 7 h / 70 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 4 h

With HgO*2HBF₄; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2012.11.110

upstream raw materials:

C₂₆H₃₀N₂O₂

3,4-dimethoxystyrene

3',4'-dimethoxyphenylglyoxal

ethylenediamine

Refernces

• 1、 Kour, Harpreet,Paul, Satya,Singh, Parvinder Pal,Gupta, Monika,Gupta, Rajive. "A simple one-pot method for the mercuric oxide mediated synthesis of piperazines via oxidative diamination of olefins". . p. 761 - 764. Retrieved 2013/02/25.