4-Hydroxyphentermine

Base Information

• Chemical Name: 4-Hydroxyphentermine
• CAS No.: 51706-55-9
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.235
• Hs Code.: 2922299090
• Mol file: 51706-55-9.mol

Synonyms:Phenol,p-(2-amino-2-methylpropyl)- (6CI); 4-(2-Amino-2,2-dimethylethyl)phenol;4-(2-Amino-2-methylpropyl)phenol; 4-(2-Methyl-2-aminopropyl)phenol;p-Hydroxyphentermine

Chemical Property of 4-Hydroxyphentermine

Chemical Property:

• Vapor Pressure: 0.00148mmHg at 25°C
• Boiling Point: 287°C at 760 mmHg
• Flash Point: 127.3°C
• PSA: 46.25000
• Density: 1.049g/cm³
• LogP: 2.37230

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Amino-2-methylpropyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxyphentermine

There total 3 articles about 4-Hydroxyphentermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-nitro-1,1-dimethyl-2-(4-hydroxyphenyl]ethane (16066-97-0) → 4-(2-amino-2-methylpropyl)phenol (51706-55-9)

Guidance literature:

With hydrogen; nickel; In methanol; at 100 ℃; for 3h; under 114000 Torr;

DOI:10.1002/ardp.19833160303

Reference yield:

(4-hydroxyphenyl)methanol (623-05-2) → 4-(2-amino-2-methylpropyl)phenol (51706-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / potassium tert-butoxide / bis-(2-methoxy-ethyl) ether / 4 h / 130 - 150 °C

2: 86 percent / H₂; HOAc / Pd/C / methanol / 16 h / 50 °C / 2585.74 Torr

With potassium tert-butylate; hydrogen; acetic acid; palladium on activated charcoal; In methanol; diethylene glycol dimethyl ether;

DOI:10.1016/j.bmcl.2006.08.010

Reference yield:

→ 4-(2-amino-2-methylpropyl)phenol (51706-55-9)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01644a031

upstream raw materials:

1-nitro-1,1-dimethyl-2-(4-hydroxyphenyl]ethane

(4-hydroxyphenyl)methanol

Downstream raw materials:

(R,S)-2-<3-<<1,1-dimethyl-2-(4-hydroxyphenyl)ethyl>amino>-2-hydroxypropoxy>-3-cyanopyridine

6-[4-(2-amino-2-methylpropyl)-phenoxy]-pyridine-3-carboxamide

6-(4-{2-[(S)-2-Hydroxy-3-(2-methylamino-3-nitro-phenoxy)-propylamino]-2-methyl-propyl}-phenoxy)-nicotinamide

6-(4-{2-[(S)-3-(2-Ethylamino-3-nitro-phenoxy)-2-hydroxy-propylamino]-2-methyl-propyl}-phenoxy)-nicotinamide

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