7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Base Information

Chemical Name:7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
CAS No.:22503-72-6
Molecular Formula:C8H9 Cl N2 O2 S
Molecular Weight:232.691
Hs Code.:2933990090
European Community (EC) Number:839-213-6
UNII:689UW7PT68
DSSTox Substance ID:DTXSID70936887
Nikkaji Number:J678.590E
Wikipedia:IDRA-21
Wikidata:Q5970086
ChEMBL ID:CHEMBL77862
Mol file:22503-72-6.mol

Synonyms:7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide;IDRA 21;IDRA-21

Suppliers and Price of 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
IDRA 21
10mg
$ 423.00

TRC
IDRA 21
250mg
$ 1540.00

Tocris
IDRA 21 ≥98%(HPLC)
50
$ 770.00

Tocris
IDRA 21 ≥98%(HPLC)
10
$ 183.00

Sigma-Aldrich
IDRA 21 ≥98%
5mg
$ 220.00

Medical Isotopes, Inc.
IDRA 21
250 mg
$ 2400.00

Labseeker
IDRA 21 95
1g
$ 338.00

Crysdot
7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine1,1-dioxide 97%
10g
$ 348.00

Crysdot
7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine1,1-dioxide 97%
25g
$ 579.00

Chemenu
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine1,1-dioxide 97%
10g
$ 328.00

Total 114 raw suppliers

Chemical Property of 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Chemical Property:

Vapor Pressure:8.98E-07mmHg at 25°C
Melting Point:209 °C(Solv: acetic acid (64-19-7))
Boiling Point:405.1°Cat760mmHg
PKA:9.78±0.40(Predicted)
Flash Point:198.8°C
PSA：66.58000
Density:1.394g/cm³
LogP:2.93740
Storage Temp.:Store at RT
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:232.0073264
Heavy Atom Count:14
Complexity:314

Purity/Quality:

99.89% ^*data from raw suppliers

IDRA 21 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1NC2=C(C=C(C=C2)Cl)S(=O)(=O)N1
Uses IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960). IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.

Technology Process of 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

There total 5 articles about 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5790-69-2
2-amino-5-chlorobenzenesulfonamide

: 64-17-5
ethanol

: 22503-72-6,163936-78-5
IDRA 21

Guidance literature:: With tert.-butylhydroperoxide; at 110 ℃; for 12h;
DOI:10.1016/j.tetlet.2018.04.054

Reference yield:

: 5790-69-2
2-amino-5-chlorobenzenesulfonamide

: 75-07-0,9002-91-9
acetaldehyde

: 22503-72-6,163936-78-5
IDRA 21

Guidance literature:: In acetonitrile;
DOI:10.1021/jm00338a008

Reference yield:

: 90794-87-9
4-Chlor-2-acetylsulfamoyl-acetanilid

: 22503-72-6,163936-78-5
IDRA 21

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH

2: acetonitrile

With sodium hydroxide; In acetonitrile;
DOI:10.1021/jm00338a008