Bis[3-(trifluoromethyl)phenyl]phosphane

Base Information

• Chemical Name: Bis[3-(trifluoromethyl)phenyl]phosphane
• CAS No.: 65796-64-7
• Molecular Formula: C14H9F6P
• Molecular Weight: 322.19
• DSSTox Substance ID: DTXSID50505217
• Wikidata: Q82360174
• Mol file: 65796-64-7.mol

Synonyms:Bis[3-(trifluoromethyl)phenyl]phosphane;65796-64-7;SCHEMBL627686;DTXSID50505217;SLEAUGLJRCPRES-UHFFFAOYSA-N

Chemical Property of Bis[3-(trifluoromethyl)phenyl]phosphane

Chemical Property:

• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 322.03460626
• Heavy Atom Count: 21
• Complexity: 305

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)PC2=CC=CC(=C2)C(F)(F)F)C(F)(F)F

Technology Process of Bis[3-(trifluoromethyl)phenyl]phosphane

There total 4 articles about Bis[3-(trifluoromethyl)phenyl]phosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

bis[3-(trifluoromethyl)phenyl]chlorophosphine (13685-25-1) → bis(α,α,α-trifluoro-3-tolyl)phosphine (65796-64-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at -78 - 20 ℃; for 1.5h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.organomet.7b00057

Reference yield: 89.0%

bis(α,α,α-trifluoro-3-tolyl)phosphine oxide (15929-44-9) → bis(α,α,α-trifluoro-3-tolyl)phosphine (65796-64-7)

Guidance literature:

With diphenylsilane;

DOI:10.1021/jo00335a020

Reference yield:

3-(trifluoromethyl)phenylmagnesium bromide (402-26-6) → bis(α,α,α-trifluoro-3-tolyl)phosphine (65796-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / diethyl ether

2: 89 percent / diphenylsilane

With diphenylsilane; In diethyl ether;

DOI:10.1021/jo00335a020

upstream raw materials:

bis(α,α,α-trifluoro-3-tolyl)phosphine oxide

3-(trifluoromethyl)phenylmagnesium bromide

3-bromo-1-trifluoromethylbenzene

bis[3-(trifluoromethyl)phenyl]chlorophosphine

Downstream raw materials:

2,11-bisbenzophenantrene

Acetylbis<3-(trifluormethyl)phenyl>phosphan

1-diphenylphosphino-2-m-bis(trifluoromethylphenyl)phosphinoethane

Trifluoracetylbis<3-(trifluormethyl)phenyl>phosphan