ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE
• CAS No.: 7625-01-6
• Molecular Formula: C12H13 N O2 S
• Molecular Weight: 235.307
• Hs Code.: 2934999090
• Mol file: 7625-01-6.mol

Synonyms:2-(Ethoxycarbonyl)-3-methyl-4H-1,4-benzothiazine;Ethyl 3-methyl-(4H)-1,4-benzothiazine-2-carboxylate; NSC 622343

Chemical Property of ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.00017mmHg at 25°C
• Melting Point: 142-144oC
• Boiling Point: 330.1°Cat760mmHg
• Flash Point: 153.4°C
• PSA: 63.63000
• Density: 1.205g/cm³
• LogP: 3.13680

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-methyl-4H-benzo[b][1,4]thiazine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE

There total 14 articles about ETHYL 3-METHYL-4H-1,4-BENZOTHIAZINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C8H16N2O2 (923001-77-8) + 2-Aminophenyl disulfide (1141-88-4) → 2-ethoxycarbonyl-3-methyl-4H-benzo<1,4>thiazine (7625-01-6)

Guidance literature:

In ethanol; for 12h; Reflux;

DOI:10.3998/ark.5550190.0007.f21

Reference yield: 92.0%

ethyl acetoacetate (141-97-9) + 2-amino-benzenethiol (137-07-5) → 2-ethoxycarbonyl-3-methyl-4H-benzo<1,4>thiazine (7625-01-6)

Guidance literature:

for 0.05h; microwave irradiation;

Reference yield: 91.0%

ethyl 3-(butylamino)but-2-enoate (5065-81-6,21759-72-8,21759-73-9) + 2-Aminophenyl disulfide (1141-88-4) → 2-ethoxycarbonyl-3-methyl-4H-benzo<1,4>thiazine (7625-01-6)

Guidance literature:

In ethanol; for 15h; Reflux;

DOI:10.3998/ark.5550190.0007.f21

upstream raw materials:

2-amino-benzenethiol

ethyl 2-chloro-3-oxo-butyrate

ethyl (2-methyl-2,3-dihydro-benzothiazol-2-yl)-acetate

ethyl (Z)-3-hydroxy-2-butenoate

Downstream raw materials:

3-methyl-5-oxo-1-phenyl-4-phenyldiazenyl-1,2-diazacyclopent-3-ene

2-Aminophenyl disulfide

C₁₈H₁₆N₄OS₂

C₁₈H₁₆N₄S₂

Refernces

• 1、 Londhe, Balaji S.,Padwal, Sudhakar L.,Bhosale, Manisha R.,Mane, Ramrao A.. "Novel synthesis of 1,4-benzothiazines in water accelerated by β-cyclodextrin". . p. 443 - 447. Retrieved 2016/01/27.
• 2、 Khairnar, Bhikan J,Salunke, Rahul S,Patil, Premchand B,Patil, Sanjay A,Kapade, Rajeshwar J,Girase, Pravin S,Chaudhari, Bhata R. "Synthesis and antimicrobial activity of some new 1, 4-benzothiazine containing thiosemicarbazides and 1, 3, 4-oxadiazole derivatives". experimental part. p. 318 - 322. Retrieved 2012/06/18.