N-Methyl-N-phenylnaphthalen-1-amine

Base Information

• Chemical Name: N-Methyl-N-phenylnaphthalen-1-amine
• CAS No.: 34160-17-3
• Molecular Formula: C17H15 N
• Molecular Weight: 233.313
• Hs Code.: 2921499090
• European Community (EC) Number: 251-854-8
• UNII: G3KH2BU7SQ
• DSSTox Substance ID: DTXSID00187764
• Nikkaji Number: J287.869K
• Wikidata: Q83059494
• Mol file: 34160-17-3.mol

Synonyms:N-Methyl-N-phenylnaphthalen-1-amine;34160-17-3;EINECS 251-854-8;G3KH2BU7SQ;UNII-G3KH2BU7SQ;SCHEMBL1414206;N-(1-Naphthyl)-N-methylaniline;DTXSID00187764;1-(N-methyl-N-phenylamino)naphthalene;1-Naphthalenamine, N-methyl-N-phenyl-;1-(N-Methyl-N-phenylamino)-naphthalene;W-110839

Chemical Property of N-Methyl-N-phenylnaphthalen-1-amine

Chemical Property:

• Vapor Pressure: 3.29E-06mmHg at 25°C
• Melting Point: 56-59 °C
• Boiling Point: 387.4°C at 760 mmHg
• PKA: 1.00±0.20(Predicted)
• Flash Point: 168.6°C
• PSA: 3.24000
• Density: 1.121g/cm³
• LogP: 4.60770
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 233.120449483
• Heavy Atom Count: 18
• Complexity: 256

Purity/Quality:

98% ^*data from raw suppliers

N-METHYL-N-PHENYLNAPHTHALEN-1-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C1=CC=CC=C1)C2=CC=CC3=CC=CC=C32

Technology Process of N-Methyl-N-phenylnaphthalen-1-amine

There total 12 articles about N-Methyl-N-phenylnaphthalen-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Bromonaphthalene (90-11-9) + N-methylaniline (100-61-8) → 1-(N-methyl-N-phenylamino)-naphthalene (34160-17-3)

Guidance literature:

With palladium diacetate; sodium t-butanolate; ruphos; In neat (no solvent); at 110 ℃; for 12h; Green chemistry;

DOI:10.1002/ejoc.201402077

Reference yield: 98.0%

N,N-dimethyl-1-naphthalenamine (86-56-6,112790-02-0,651316-60-8) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 1-(N-methyl-N-phenylamino)-naphthalene (34160-17-3)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; ammonium bicarbonate; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol4029258

Reference yield: 98.0%

→ 1-(N-methyl-N-phenylamino)-naphthalene (34160-17-3)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; ammonium bicarbonate; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere;

upstream raw materials:

N-phenyl-1-naphthylamine

dimethyl sulfate

methyl iodide

1,2-diethynylbenzene

Downstream raw materials:

[4-(di-morpholin-4-yl-phosphinothioyl)-phenyl]-methyl-naphthalen-1-yl-amine

4-[N-(4-Dibromophosphino-1-naphthyl)-N-methylamino]phenylphosphinothioic dimorpholide

Refernces

• 1、 Chen, Zicong,Chen, Xiangmeng,So, Chau Ming. "Palladium-catalyzed c(sp2)-n bond cross-coupling with triaryl phosphates". . . Retrieved 2019/05/22.
• 2、 -. "Method for catalyzing nitro-arene and amine compound to be synthesized into aromatic amine compounds through palladium/imidazolium salt". Paragraph 0121-0125. . Retrieved 2019/10/01.