2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE

Base Information

• Chemical Name: 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE
• CAS No.: 65964-62-7
• Molecular Formula: C14H11ClN2
• Molecular Weight: 242.708
• Mol file: 65964-62-7.mol

Synonyms:2-(4-CHLOROPHENYL)-7-METHYLIMIDAZO[1,2-A]PYRIDINE;2-(4-Chloro-phenyl)-7-methyl-imidazo[1,2-a]pyridine;2-(4-Chlor-phenyl)-7-methyl-imidazo[1,2-a]pyridin;2-(p-Chlorphenyl)-7-methyl-imidazo<1,2-a>pyridin;

Chemical Property of 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE

Chemical Property:

• PSA: 17.30000
• LogP: 3.96310

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Chloro-phenyl)-7-methyl-imidazo[1,2-a]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE

There total 10 articles about 2-(4-CHLORO-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(4-chlorophenyl)-3-iodo-7-methylimidazo[1,2-a]pyridine → 2-(4-chlorophenyl)-7-methyl-imidazo[1,2-a]pyridine (65964-62-7)

Guidance literature:

With 9-N-methylamino-1-oxophenalene; potassium tert-butylate; potassium; In 1,4-dioxane; dimethyl sulfoxide; at 20 ℃; for 24h; Inert atmosphere; Glovebox;

DOI:10.1021/acs.joc.1c00573

Reference yield: 79.0%

2-Amino-4-methylpyridine (695-34-1) + para-chloroacetophenone (99-91-2) → 2-(4-chlorophenyl)-7-methyl-imidazo[1,2-a]pyridine (65964-62-7)

Guidance literature:

With 1,10-Phenanthroline; copper(II) acetate monohydrate; zinc(II) iodide; In 1,2-dichloro-benzene; at 120 ℃; for 24h;

DOI:10.1002/adsc.201300298

Reference yield: 79.0%

2-Amino-4-methylpyridine (695-34-1) + 1-chloro-4-(2-nitrovinyl)benzene (706-07-0,5153-70-8) → 2-(4-chlorophenyl)-7-methyl-imidazo[1,2-a]pyridine (65964-62-7)

Guidance literature:

With iron(III) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1002/adsc.201201112

upstream raw materials:

1-(2-(4-chlorophenyl)-2-oxoethyl)-4-methylpyridinium bromide

picoline

4-chlorobenzoylmethyl bromide

2-Amino-4-methylpyridine