2-(4-Methoxyphenyl)-7-methylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-7-methylimidazo[1,2-a]pyridine
• CAS No.: 65964-63-8
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• DSSTox Substance ID: DTXSID301325648
• Nikkaji Number: J3.353.107I
• ChEMBL ID: CHEMBL1414273
• Mol file: 65964-63-8.mol

Synonyms:2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine;65964-63-8;2-(4-Methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 2-(4-methoxyphenyl)-7-methyl-;Cambridge id 6445534;Oprea1_582362;MLS000764542;SCHEMBL6544442;CHEMBL1414273;MJFVSLMOLHCTOE-UHFFFAOYSA-N;DTXSID301325648;HMS2767I24;BBL020194;STK827937;AKOS000527483;SMR000290147;CS-0326716;AE-848/30897049;SR-01000447076;SR-01000447076-1;Z57217598

Chemical Property of 2-(4-Methoxyphenyl)-7-methylimidazo[1,2-a]pyridine

Chemical Property:

• PSA: 26.53000
• LogP: 3.31830
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 238.110613074
• Heavy Atom Count: 18
• Complexity: 276

Purity/Quality:

99% ^*data from raw suppliers

2-(4-METHOXY-PHENYL)-7-METHYL-IMIDAZO[1,2-A]PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=NC(=CN2C=C1)C3=CC=C(C=C3)OC

Technology Process of 2-(4-Methoxyphenyl)-7-methylimidazo[1,2-a]pyridine

There total 10 articles about 2-(4-Methoxyphenyl)-7-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Amino-4-methylpyridine (695-34-1) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(4-methoxyphenyl)-7-methyl-imidazo[1,2-a]pyridine (65964-63-8)

Guidance literature:

In neat (no solvent); at 25 - 30 ℃; Milling; Green chemistry;

DOI:10.1002/jhet.4164

Reference yield: 85.0%

2-Amino-4-methylpyridine (695-34-1) + 4-Methoxypropiophenone (121-97-1) → 2-(4-methoxyphenyl)-7-methyl-imidazo[1,2-a]pyridine (65964-63-8)

Guidance literature:

4-Methoxypropiophenone; With aluminum (III) chloride; bromine; In methanol; Cooling with ice;

2-Amino-4-methylpyridine; With sodium carbonate; In methanol; water; at 35 ℃; for 0.333333h;

Reference yield: 80.0%

→ 2-(4-methoxyphenyl)-7-methyl-imidazo[1,2-a]pyridine (65964-63-8)

Guidance literature:

With dmap; iodine; at 20 ℃; for 2.5h; Sealed tube;

upstream raw materials:

2-Amino-4-methylpyridine

2-Bromo-4'-methoxyacetophenone

1-(4-methoxyphenyl)ethanone

1-methoxy-4-(2-nitro-vinyl)-benzene

Downstream raw materials:

7-[(E)-2-thienylvinyl]-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine

C₁₉H₂₄N₃O⁽¹⁺⁾*I^(1-)

[2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]acetic acid

1-(2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]-3-pyridinyl)-N,N-dimethylmethylamine