Methyl 6-chloro-4-hydrazinonicotinate

Base Information

• Chemical Name: Methyl 6-chloro-4-hydrazinonicotinate
• CAS No.: 65973-40-2
• Molecular Formula: C7H8ClN3O2
• Molecular Weight: 201.61000
• Hs Code.: 2933399090
• Mol file: 65973-40-2.mol

Synonyms:methyl 6-chloro-4-hydrazinonicotinate;methylchlorohydrazinonicotinate;6-chloro-4-hydrazino-3-pyridinecarboxylic acid,methyl ester;

Chemical Property of Methyl 6-chloro-4-hydrazinonicotinate

Chemical Property:

• Melting Point: 150-152°
• PSA: 77.24000
• LogP: 1.58050

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 6-chloro-4-hydrazinonicotinate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-chloro-4-hydrazinonicotinate

There total 2 articles about Methyl 6-chloro-4-hydrazinonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.29%

methyl 4,6-dichloropyridine-3-carboxylate (65973-52-6) → methyl 6-chloro-4-hydrazinylnicotinate (65973-40-2)

Guidance literature:

With hydrazine hydrate; In methanol; at 0 ℃; for 12h;

Reference yield:

→ methyl 6-chloro-4-hydrazinylnicotinate (65973-40-2)

Guidance literature:

N2H4, entspr. Chlorid;

Reference yield:

methyl 6-chloro-4-hydrazinylnicotinate (65973-40-2) → 2,4-dimethyl-4H-pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-one (65973-43-5)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol

2: triethylamine / N-methyl-acetamide; palladium on charcoal; water

3: N-methyl-acetamide; water; potassium carbonate

triethylamine; In N-methyl-acetamide; methanol; palladium on charcoal; water; potassium carbonate;

upstream raw materials:

methyl 4,6-dichloropyridine-3-carboxylate

Downstream raw materials:

2,4-dimethyl-4H-pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5-one