65973-52-6

Basic information

• Product Name: Methyl 4,6-dichloronicotinate
• Synonyms: 4,6-Dichloronicotinic acid methyl ester;Methyl 4,6-dichloronicotinate;methyl 4,6-dichloropyridine-3-carboxylate;Methyl 4,6-dichloronicotinate 95+%;3-Pyridinecarboxylic acid, 4,6-dichloro-, Methyl ester;Methyl 4,6-dichloropyridine-3-carboxylate, 2,4-Dichloro-5-(methoxycarbonyl)pyridine;Methyl 4,6-dichloronicotinte;4,6-Dichloro-pyridin-3-carboxylic acid methyl ester
• CAS NO: 65973-52-6
• Molecular Formula: C₇H₅Cl₂NO₂
• Molecular Weight: 206.03
• Product Categories: Esters;Pyridines;Heterocyclic Compounds;Pyridine
• Mol File: 65973-52-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 41-43°
• Boiling Point: 260 °C at 760 mmHg
• Flash Point: 111.1 °C
• Appearance: /Solid
• Density: 1.426 g/cm³
• Vapor Pressure: 0.0125mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.24±0.10(Predicted)
• CAS DataBase Reference: Methyl 4,6-dichloronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4,6-dichloronicotinate(65973-52-6)
• EPA Substance Registry System: Methyl 4,6-dichloronicotinate(65973-52-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 65973-52-6(Hazardous Substances Data)

Usage

General Description

Methyl 4,6-dichloronicotinate is a chemical compound that belongs to the class of organic compounds known as pyridinecarboxylic acids. It is a derivative of nicotinic acid and contains two chlorine atoms attached to the 4 and 6 positions of the pyridine ring. Methyl 4,6-dichloronicotinate is often used in the synthesis of pharmaceuticals, agrochemicals, and organic intermediates due to its unique structure and properties. Methyl 4,6-dichloronicotinate is known for its low toxicity and is considered to be relatively stable under normal conditions. It is important to handle and store this chemical with care to prevent any potential risks associated with its usage.

InChI:InChI=1/C7H5Cl2NO2/c1-12-7(11)4-3-10-6(9)2-5(4)8/h2-3H,1H3

Upstream product

• 93-60-7 methyl 3-pyridinecarboxylate 
• 79398-27-9 methyl 4,6-dihydroxypyridine-3-carboxylate 
• 73027-79-9 4,6-dichloro-nicotinic acid 
• 74-88-4 methyl iodide 
• 61043-19-4 2-[1-Ethoxy-meth-(Z)-ylidene]-3-oxo-pentanedioic acid dimethyl ester 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 79398-27-9 1,6-dihydro-4-hydroxy-6-oxo-pyridine-3-carboxylic acid methyl ester 
• 67-56-1 methanol 

Downstream Products

• 1386447-27-3 4-chloro-3-[(7-methoxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-3-carbonyl)-amino]-benzoic acid methyl ester 
• 1386447-28-4 7-methoxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-3-carboxylic acid (5-benzylcarbamoyl-2-chloro-phenyl)-amide 
• 1386447-75-1 [4-benzylamino-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-methanol 
• 1386447-84-2 4-chloro-3-[(7-methoxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-3-carbonyl)-amino]-benzoic acid 
• 1386447-54-6 3-{[7-(4-methyl-piperazin-1-yl)-2-oxo-1,2-dihydro-[1,6]naphthyridine-3-carbonyl]-amino}-benzoic acid methyl ester 
• 886372-05-0 methyl 4-chloro-6-methylpyridine-3-carboxylate 
• 1454914-30-7 methyl 4-(4-chloro-2-fluorophenyl)-6-methylnicotinate 
• 1454914-31-8 (4-(4-chloro-2-fluorophenyl)-6-methylpyridin-3-yl) methanol 
• 84332-02-5 methyl 6-chloro-4-methoxypyridine-3-carboxylate 
• 1263059-66-0 (6-chloro-4-methoxypyridin-3-yl)methanol 
• 1256823-05-8 6-chloro-4-methoxypyridine-3-carbaldehyde 

Relevant articles and documents

HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Preparation method of 6-chloro-4-hydroxypyridine-3-carbaldehyde

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