1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Base Information

Chemical Name:1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
CAS No.:66000-41-7
Molecular Formula:C10H8F3N3
Molecular Weight:227.189
Hs Code.:
European Community (EC) Number:961-213-0
DSSTox Substance ID:DTXSID401226469

Synonyms:1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine;66000-41-7;1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine;1-[3-(TRIFLUOROMETHYL)PHENYL]PYRAZOL-3-AMINE;1-(3-trifluoromethyl-phenyl)-1H-pyrazol-3-ylamine;SCHEMBL45043;TQP1410;DTXSID401226469;AKOS011972481;AM20040971;CS-0233258;EN300-132125;G49661;1H-Pyrazol-3-amine, 1-[3-(trifluoromethyl)phenyl]-;Z995041314

Suppliers and Price of 1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:227.06703175
Heavy Atom Count:16
Complexity:244

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)N2C=CC(=N2)N)C(F)(F)F

Technology Process of 1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

There total 4 articles about 1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1354722-12-5
3-nitro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole

: 66000-41-7
1-(3-(trifluoromethyl)phenyl)-3-amino-1H-pyrazole

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

Reference yield:

: 66000-40-6
3-amino-1-<3-(trifluoromethyl)phenyl>-2-pyrazoline

: 66000-41-7
1-(3-(trifluoromethyl)phenyl)-3-amino-1H-pyrazole

Guidance literature:: With N-Bromosuccinimide; In toluene; for 1h; Reflux;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 66000-41-7
1-(3-(trifluoromethyl)phenyl)-3-amino-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2: hydrogen / palladium on activated charcoal / methanol / 20 °C

With copper(l) iodide; hydrogen; potassium carbonate; L-proline; palladium on activated charcoal; In methanol; dimethyl sulfoxide;