1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone

Base Information

Chemical Name:1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone
CAS No.:66158-68-7
Molecular Formula:C7H13NO2
Molecular Weight:143.186
Hs Code.:2933990090
European Community (EC) Number:831-732-6
DSSTox Substance ID:DTXSID70498490
Wikidata:Q82348576
Mol file:66158-68-7.mol

Synonyms:1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone;66158-68-7;1-[(2S)-2-(HYDROXYMETHYL)PYRROLIDIN-1-YL]ETHANONE;1-[(2S)-2-(Hydroxymethyl)pyrrolidin-1-yl]ethan-1-one;acetylprolinol;SCHEMBL12136795;DTXSID70498490;AKOS006315787;AM101105;CS-0256427;E82604;EN300-6487233;(S)-1-(2-(hydroxymethyl)pyrrolidin-1-yl)ethanone;(S)-1-(2-(Hydroxymethyl)pyrrolidin-1-yl)ethan-1-one

Suppliers and Price of 1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone 95+%
1g
$ 710.00

Chemenu
(S)-1-(2-(hydroxymethyl)pyrrolidin-1-yl)ethanone 95%
1g
$ 593.00

American Custom Chemicals Corporation
1-((S)-2-HYDROXYMETHYL-PYRROLIDIN-1-YL)ETHANONE 95.00%
5MG
$ 504.32

American Custom Chemicals Corporation
1-((S)-2-HYDROXYMETHYL-PYRROLIDIN-1-YL)ETHANONE 95.00%
1G
$ 1056.30

AK Scientific
1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone
5g
$ 1577.00

AK Scientific
1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone
500mg
$ 474.00

Total 9 raw suppliers

Chemical Property of 1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone

Chemical Property:

PSA：40.54000
LogP:-0.07250
XLogP3:-0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:143.094628657
Heavy Atom Count:10
Complexity:136

Purity/Quality:

97% ^*data from raw suppliers

1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CCCC1CO
Isomeric SMILES:CC(=O)N1CCC[C@H]1CO

Technology Process of 1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone

There total 4 articles about 1-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 66158-68-7,123958-87-2
(S)-1-(2-(hydroxymethyl) pyrrolidin-1-yl)ethanone

Guidance literature:: With potassium carbonate; In dichloromethane; for 1.5h;
DOI:10.1021/jm00109a013

Reference yield: 92.0%

: 2033-24-1
cycl-isopropylidene malonate

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 66158-68-7,123958-87-2
(S)-1-(2-(hydroxymethyl) pyrrolidin-1-yl)ethanone

Guidance literature:: In toluene; for 12h; Inert atmosphere; Reflux;
DOI:10.1039/d0gc03731a

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 66158-68-7,123958-87-2
(S)-1-(2-(hydroxymethyl) pyrrolidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / LiAlH₄ / tetrahydrofuran / 72 h / Heating

2: 72 percent / 1 h / 65 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/0022-328X(89)87277-8