1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(5-methylpyrazin-2-yl)propan-1-one

Base Information

Chemical Name:1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(5-methylpyrazin-2-yl)propan-1-one
CAS No.:108905-68-6
Molecular Formula:C₁₃H₁₅BrN₄OS
Molecular Weight:355.258
Hs Code.:

Synonyms:1-Propanone,1-[4-bromo-1-methyl-2-(methylthio)-1H-imidazol-5-yl]-2-(5-methylpyrazinyl)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(5-methylpyrazin-2-yl)propan-1-one

Chemical Property:

Vapor Pressure:1.11E-10mmHg at 25°C
Boiling Point:514.2°Cat760mmHg
Flash Point:264.8°C
Density:1.53g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(5-methylpyrazin-2-yl)propan-1-one

There total 1 articles about 1-[4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]-2-(5-methylpyrazin-2-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108905-64-2
2-(5-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethan-1-one

: 74-88-4
methyl iodide

: 1-(5-Bromo-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl)-2-methyl-2-(5-methyl-pyrazin-2-yl)-propan-1-one

: 108905-68-6
2-(5-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)propan-1-one

Guidance literature:: With potassium hexamethylsilazane; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, toluene, -78 deg C, 30 min, 2) to room temperature, 54 h;
DOI:10.1021/jo00031a017

Reference yield: 96.0%

: 108905-68-6
2-(5-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)propan-1-one

: 138335-82-7,138335-83-8
2-(5-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)propan-1-ol

Guidance literature:: With sodium tetrahydroborate; In ethanol; 0 deg C to room temperature, overnight;
DOI:10.1021/jo00031a017

Reference yield:

: 108905-68-6
2-(5-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)propan-1-one

: 138335-90-7
(Z)-2-(5-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)prop-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NaBH₄ / ethanol / 0 deg C to room temperature, overnight

2: methanesulfonic acid / toluene / 0.33 h / Heating

With sodium tetrahydroborate; methanesulfonic acid; In ethanol; toluene;
DOI:10.1021/jo00031a017