Prostaglandin h2

Base Information

• Chemical Name: Prostaglandin h2
• CAS No.: 42935-17-1
• Molecular Formula: C20H32 O5
• Molecular Weight: 352.471
• UNII: J670X3LRU2
• DSSTox Substance ID: DTXSID80903949
• Nikkaji Number: J16.429A
• Wikipedia: Prostaglandin_H2
• Wikidata: Q416567
• Pharos Ligand ID: 5TDRM218TAGC
• Metabolomics Workbench ID: 2380
• ChEMBL ID: CHEMBL2074582
• Mol file: 42935-17-1.mol

Synonyms:PGH(2);PGH2;Prostaglandin H2

Chemical Property of Prostaglandin h2

Chemical Property:

• Vapor Pressure: 1.16E-11mmHg at 25°C
• Melting Point: 42.8oC
• Boiling Point: 490.1°C at 760 mmHg
• PKA: 4.76±0.10(Predicted)
• Flash Point: -17 °C
• PSA: 75.99000
• Density: 1.129g/cm³
• LogP: 4.02010
• Storage Temp.: −70°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• Exact Mass: 352.22497412
• Heavy Atom Count: 25
• Complexity: 459

Purity/Quality:

95% ^*data from raw suppliers

Prostaglandin H2 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xi
• Statements: 11-36-66-67
• Safety Statements: 9-16-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)OO2)O
• Isomeric SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)OO2)O
• Description: Prostaglandin H2 (PGH2) was first isolated from incubations of arachidonic acid with ovine seminal vesicle microsomes, and was described as a potent vasoconstrictor. PGH2 is the precursor for all 2-series PGs and thromboxanes (TXs), and is a TP receptor agonist which irreversibly aggregates human platelets at 50-100 ng/ml.
• Uses: PGH2 (Prostaglandin H2) is a thromboxane A2 precursor and a platelet aggregator of vascular smooth muscle contraction.

Technology Process of Prostaglandin h2

There total 3 articles about Prostaglandin h2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

all cis 5,8,11,14-eicosatetraenoic acid (506-32-1,236743-58-1) → prostaglandin H2 (42935-17-1,127969-05-5)

Guidance literature:

With sodium phosphate buffer; oxygen; In ethanol; at 25 ℃; for 0.05h; microsomes, pH 7.8;

DOI:10.1021/ja00332a049

Reference yield:

Prostaglandin G2 (51982-36-6) → prostaglandin H2 (42935-17-1,127969-05-5)

Guidance literature:

Reference yield:

→ prostaglandin H2 (42935-17-1,127969-05-5)

Guidance literature:

9β,11β-Dibromo-9,11-dideoxy-prostaglandin F(2α) (5), AgAc(f)/H2O2;

DOI:10.1021/ja00509a045

upstream raw materials:

all cis 5,8,11,14-eicosatetraenoic acid

Prostaglandin G₂

Downstream raw materials:

Prostacyclin

prostaglandin D₂

dinoprostone

levuglandin LGE₂