2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol

Base Information

Chemical Name:2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol
CAS No.:133174-26-2
Molecular Formula:C25H26O3
Molecular Weight:374.48
Hs Code.:
DSSTox Substance ID:DTXSID80927988
Nikkaji Number:J477.936C
ChEMBL ID:CHEMBL282530

Synonyms:2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol;L 670,630;L 670630;L-670,630;L-670630

Suppliers and Price of 2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol

Chemical Property:

Vapor Pressure:2.25E-13mmHg at 25°C
Boiling Point:565.1°Cat760mmHg
Flash Point:295.6°C
Density:1.155g/cm³
XLogP3:6.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:374.18819469
Heavy Atom Count:28
Complexity:441

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC2=CC(=C(C=C21)O)CCCOC3=CC=CC=C3)CCC4=CC=CC=C4

Technology Process of 2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol

There total 14 articles about 2,3-Dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 138854-30-5
5-(benzyloxy)-2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)benzofuran

: 133174-26-2
2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 0.166667h;
DOI:10.1021/jm00085a019

Reference yield:

: 13391-28-1
5-methoxybenzofuran

: 133174-26-2
2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C

2: 58 percent / AlCl₃, tert-butylamine-borane / toluene / 2 h / 5 °C

3: 99 percent / trifluoroacetic acid, triethylsilane / 1.) 5 deg C, 60 min, 2.) RT, 18 h

4: 98 percent / ethanethiol, lithium hydride / dimethylformamide / 3 h / Heating

5: 1.) phenylboronic acid, propionic acid, 2.) AlCl₃, tert-butylamine-borane / 1.) toluene, reflux, 4 h, 2.) CH₂Cl₂, 0 deg C, 2 h

With triethylsilane; n-butyllithium; aluminium trichloride; lithium hydride; borane tert-butylamine; propionic acid; trifluoroacetic acid; ethanethiol; phenylboronic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00085a019

Reference yield:

: 122-78-1
phenylacetaldehyde

: 133174-26-2
2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C

2: 58 percent / AlCl₃, tert-butylamine-borane / toluene / 2 h / 5 °C

3: 99 percent / trifluoroacetic acid, triethylsilane / 1.) 5 deg C, 60 min, 2.) RT, 18 h

4: 98 percent / ethanethiol, lithium hydride / dimethylformamide / 3 h / Heating

5: 1.) phenylboronic acid, propionic acid, 2.) AlCl₃, tert-butylamine-borane / 1.) toluene, reflux, 4 h, 2.) CH₂Cl₂, 0 deg C, 2 h

With triethylsilane; n-butyllithium; aluminium trichloride; lithium hydride; borane tert-butylamine; propionic acid; trifluoroacetic acid; ethanethiol; phenylboronic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00085a019