13391-28-1

Basic information

• Product Name: 5-Methoxybenzofuran
• Synonyms: 5-METHOXYBENZOFURAN;5-methoxy-benzofura;Benzofuran, 5-methoxy-;5-methoxy-1-benzofuran;5-Methoxybenzo[b]furan
• CAS NO: 13391-28-1
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.16
• Mol File: 13391-28-1.mol
• Article Data: 31

Chemical Properties

• Melting Point: 31 °C
• Boiling Point: 123 °C
• Flash Point: 99.13 °C
• Appearance: /
• Density: 1.137 g/cm³
• Vapor Pressure: 0.181mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Methoxybenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxybenzofuran(13391-28-1)
• EPA Substance Registry System: 5-Methoxybenzofuran(13391-28-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 13391-28-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 19, p. 257, 1989 DOI: 10.1080/00397918908050977

InChI:InChI=1/C9H8O2/c1-10-8-2-3-9-7(6-8)4-5-11-9/h2-6H,1H3

Upstream product

• 69034-13-5 p-methoxyphenoxyacetaldehyde diethyl acetal 
• 23145-07-5 5-bromobenzofuran 
• 38050-71-4 9-methoxy-9-BBN 
• 33320-42-2 5-methoxy-2,3-dihydro-benzofuran-3-ol 
• 75717-53-2 2-chloro-1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 5394-57-0 2-(4-methoxyphenoxy)ethanol 
• 68426-09-5 (4-methoxyphenoxy)acetaldehyde 
• 13196-10-6 benzofuran-5-ol 
• 74-88-4 methyl iodide 
• 935-50-2 4,4-dimethoxycyclohexa-2,5-dienone 
• 68426-08-4 1-(2,2-dimethoxyethoxy)-4-methoxybenzene 
• 93198-67-5 methyl (E)-3-(2-hydroxy-5-methoxyphenyl)acrylate 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 

Downstream Products

• 139201-44-8 2-(1-hydroxy-2-phenylethyl)-5-methoxybenzofuran 
• 77440-98-3 chloro-6 methoxy-5 benzofuranne 
• 77440-95-0 chloro-2 methoxy-5 benzofuranne 
• 77440-97-2 chloro-4 methoxy-5 benzofuranne 
• 77440-96-1 chloro-3 methoxy-5 benzofuranne 
• 13391-32-7 2-ethyl-4-methoxy-phenol 
• 58546-89-7 1-benzofuran-5-amine 
• 138854-19-0 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 138854-22-5 6-<3-<(3-carbomethoxy-2-methoxyquinolin-7-yl)thio>propyl>-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 139201-54-0 6-<3-<(3-carboxy-2-methoxyquinolin-7-yl)thio>propyl>-2,3-dihydro-2-(2-phenylethyl)-5-benzofuranol 
• 139201-52-8 2-<<3-<2,3-dihydro-5-(benzyloxy)-2-(2-phenylethyl)benzofuran-6-yl>propyl>thio>benzothiazole 
• 138854-35-0 5-(benzyloxy)-6-<3-(4-carbomethoxyphenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran 
• 138854-20-3 5-(benzyloxy)-2,3-dihydro-2-(2-phenylethyl)-6-<3-<4-(1H-tetrazol-5-yl)phenoxy>propyl>benzofuran 
• 138854-21-4 5-(benzyloxy)-6-<3-<(3-carbomethoxy-2-methyoxyquinolin-7-yl)thio>propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran 

Relevant articles and documents

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Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

STABLE SOLID DISPERSIONS OF B-RAF KINASE DIMER INHIBITOR, METHODS OF PREPARATION, AND USES THEREFOR

Disclosed herein is a physically stable solid dispersion comprising Compound 1, i.e., the B-RAF kinase dimer inhibitor 1- ( (1S, 1aS, 6bS) -5- ( (7-oxo-5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-4-yl) oxy) -1a,6b-dihydro-1H-cyclopropa [b] benzofuran-1-yl) -3- (2, 4, 5-trifluorophenyl) urea and a specific stabilizing polymer, the method for preparing the same, and the uses of the solid dispersion. Also disclosed herein is the crystalline form of Compound 1.