Technology Process of Sulfasalazine IMpurity D
There total 9 articles about Sulfasalazine IMpurity D which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
Reagent/catalyst;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrahydrofuran / 60 °C
2: Lindlar's catalyst; hydrogen / ethanol / 20 °C
3: peroxyacetic acid / dichloromethane / 2 h / 25 °C
4: acetic acid / toluene / 90 °C
5: potassium hydroxide; methanol / 1 h / 80 °C
6: thionyl chloride / dichloromethane / 2 h / -20 °C
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
With
methanol; thionyl chloride; peroxyacetic acid; Lindlar's catalyst; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine; dmap / dichloromethane / 20 °C
2: Lindlar's catalyst; hydrogen / methanol / 20 °C
3: acetic acid / toluene / 90 °C
4: potassium hydroxide; methanol / 1 h / 80 °C
5: thionyl chloride / dichloromethane / 2 h / -20 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
With
methanol; dmap; thionyl chloride; Lindlar's catalyst; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
methanol; dichloromethane; toluene;
