Chemical Property of 4-Nitrobenzenesulfonyl chloride
Chemical Property:
- Appearance/Colour:yellow to brown powder
- Vapor Pressure:9.33E-05mmHg at 25°C
- Melting Point:75 °C
- Refractive Index:1.588
- Boiling Point:349.7 °C at 760 mmHg
- Flash Point:165.3 °C
- PSA：88.34000
- Density:1.606 g/cm3
- LogP:3.12630
- Storage Temp.:Store below +30°C.
- Sensitive.:Moisture Sensitive
- Solubility.:soluble in Toluene
- Water Solubility.:Insoluble
- XLogP3:2.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:1
- Exact Mass:220.9549565
- Heavy Atom Count:13
- Complexity:283
- Purity/Quality:
-
99%, *data from raw suppliers
4-Nitrobenzenesulfonyl Chloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
C
- Hazard Codes:C
- Statements:
34-52/53
- Safety Statements:
26-36/37/39-45-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Nitrogen Compounds -> Other Aromatics (Nitrogen)
- Canonical SMILES:C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)Cl
-
Uses
4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis. 4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate). 4-Nitrobenzenesulfonyl chloride was used in the synthesis of [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate)hydroxylamines of sulfadiazine and sulfamethoxazolesolution phase peptide using N-nosyl-α-amino acids.
