Technology Process of 1,4-Benzenediol, 2-methyl-5-(1,2,2-trimethylcyclopentyl)-, (R)-
There total 19 articles about 1,4-Benzenediol, 2-methyl-5-(1,2,2-trimethylcyclopentyl)-, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1S,2S)-2-(2,5-Dimethoxy-4-methyl-phenyl)-1,2-dimethyl-cyclopentanecarbaldehyde;
With
hydrazine dihydrochloride; hydrazine;
In
diethylene glycol;
at 125 ℃;
With
potassium hydroxide;
at 210 ℃;
With
boron tribromide;
In
dichloromethane;
at -70 - 20 ℃;
DOI:10.1016/S0040-4039(02)02674-6
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 80 percent / LDA / tetrahydrofuran / 8 h / -70 - 20 °C
2: 100 percent / PhCH=Ru(Cl)2(PCy3)2 / CH2Cl2 / 5 h / 20 °C
3: 85 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / 12 h / -30 - 20 °C
4: H2 / 10 percent Pd-C / ethanol / 3 h
5: LAH / diethyl ether / 0.33 h / 0 °C
6: PCC; silica gel / CH2Cl2 / 1 h / 20 °C
7: N2H4*H2O; KOH / various solvent(s) / 12 h / 190 °C
8: 98 percent / BBr3 / CH2Cl2 / 2 h / -70 - 20 °C
With
potassium hydroxide; lithium aluminium tetrahydride; hydrogen; silica gel; boron tribromide; hydrazine hydrate; pyridinium chlorochromate; lithium diisopropyl amide;
palladium on activated charcoal; Grubbs catalyst first generation;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2005.06.156
