2-Pyrrolidineethanol, (S)-

Base Information

Chemical Name:2-Pyrrolidineethanol, (S)-
CAS No.:66401-62-5
Molecular Formula:C₆H₁₃NO
Molecular Weight:115.175
Hs Code.:
DSSTox Substance ID:DTXSID70472018
Wikidata:Q82300760

Synonyms:2-Pyrrolidineethanol, (S)-;66401-62-5;2-[(2S)-pyrrolidin-2-yl]ethanol;(S)-2-PYRROLIDIN-2-YL-ETHANOL;(2s)-2-(2-hydroxyethyl)pyrrolidine;SCHEMBL1190914;DTXSID70472018;JZXVADSBLRIAIB-LURJTMIESA-N;AKOS006354278;(S)-2-(pyrrolidin-2-yl)ethan-1-ol

Suppliers and Price of 2-Pyrrolidineethanol, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2S)-2-PYRROLIDINEETHANOL 95.00%
5MG
$ 502.78

AccelPharmtech
(2S)-2-Pyrrolidineethanol 97.00%
25G
$ 11400.00

AccelPharmtech
(2S)-2-Pyrrolidineethanol 97.00%
5G
$ 6050.00

AccelPharmtech
(2S)-2-Pyrrolidineethanol 97.00%
1G
$ 3510.00

Total 3 raw suppliers

Chemical Property of 2-Pyrrolidineethanol, (S)-

Chemical Property:

Vapor Pressure:0.034mmHg at 25°C
Boiling Point:214.5±13.0 °C(Predicted)
PKA:15.03±0.10(Predicted)
PSA：32.26000
Density:0.961±0.06 g/cm3(Predicted)
LogP:0.44960
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:115.099714038
Heavy Atom Count:8
Complexity:65.5

Purity/Quality:

99% ^*data from raw suppliers

(2S)-2-PYRROLIDINEETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)CCO
Isomeric SMILES:C1C[C@H](NC1)CCO

Technology Process of 2-Pyrrolidineethanol, (S)-

There total 5 articles about 2-Pyrrolidineethanol, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 198493-30-0
tert-butyl (2S)-2-(2-oxoethyl)pyrrolidine-1-carboxylate

: 66401-62-5
(S)-2-(pyrrolidin-2-yl)ethan-1-ol

Guidance literature:: tert-butyl (2S)-2-(2-oxoethyl)pyrrolidine-1-carboxylate; With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

With trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield:

: (S)-2-pyrrolidineacetic acid hydrobromide

: 7757-82-6
sodium sulfate

: 66401-62-5
(S)-2-(pyrrolidin-2-yl)ethan-1-ol

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 66401-62-5
(S)-2-(pyrrolidin-2-yl)ethan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / dichloromethane / 16 h / 20 °C

2.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 6 h / 20 °C

3.1: hydrogenchloride / methanol / 16 h / 20 °C

3.2: 1 h / 20 °C / pH 10

4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.2: 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; Dess-Martin periodane; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane;