2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4R,5R)-5-[2-[[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro -5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl]sulfon yl]ethyl]tetrahydro-4-(hydroxymethyl)-2-furanyl]-5-methyl-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4R,5R)-5-[2-[[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro -5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl]sulfon yl]ethyl]tetrahydro-4-(hydroxymethyl)-2-furanyl]-5-methyl-
CAS No.:664329-45-7
Molecular Formula:C31H38N4O11S
Molecular Weight:674.729
Hs Code.:

2,4(1H,3H)-Pyrimidinedione,
1-[(2R,4R,5R)-5-[2-[[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro
-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl]sulfon
yl]ethyl]tetrahydro-4-(hydroxymethyl)-2-furanyl]-5-methyl-

Synonyms:

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4R,5R)-5-[2-[[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro -5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl]sulfon yl]ethyl]tetrahydro-4-(hydroxymethyl)-2-furanyl]-5-methyl-

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4R,5R)-5-[2-[[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro -5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl]sulfon yl]ethyl]tetrahydro-4-(hydroxymethyl)-2-furanyl]-5-methyl-

There total 12 articles about 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4R,5R)-5-[2-[[[(2R,3S,5R)-2-[2-(benzoyloxy)ethyl]-5-(3,4-dihydro -5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3-furanyl]methyl]sulfon yl]ethyl]tetrahydro-4-(hydroxymethyl)-2-furanyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 664329-39-9
C₄₇H₅₆N₄O₁₁SSi

: 664329-45-7
Benzoic acid 2-[(2R,3S,5R)-3-{2-[(2R,3R,5R)-3-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethanesulfonylmethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1002/hlca.200390244

Reference yield:

: 651020-33-6
1-[3'-[[[(tert-butyl)diphenylsilyl]oxy]methyl]-2',3',5'-trideoxy-β-D-erythro-hexofuranosyl]thymine

: 664329-45-7
Benzoic acid 2-[(2R,3S,5R)-3-{2-[(2R,3R,5R)-3-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethanesulfonylmethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

2: 82 percent / Cs₂CO₃ / dimethylformamide / 4 h / 45 °C

3: oxone; NaOAc / methanol; tetrahydrofuran; H₂O

4: 350 mg / oxone; NaOAc / methanol; tetrahydrofuran; H₂O / 2 h

5: 99 percent / ZnCl₂*Et₂O / CH₂Cl₂

6: 71 percent / pyridine; N,N-dimethylpyridin-4-amine / 5 h / 20 °C

7: 91 percent / Bu₄NF / tetrahydrofuran / 1.5 h / 20 °C

With pyridine; dmap; Oxone; zinc chloride diethyl ether; tetrabutyl ammonium fluoride; sodium acetate; caesium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390244

Reference yield:

: 98-88-4
benzoyl chloride

: 664329-45-7
Benzoic acid 2-[(2R,3S,5R)-3-{2-[(2R,3R,5R)-3-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethanesulfonylmethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / pyridine; N,N-dimethylpyridin-4-amine / 5 h / 20 °C

2: 91 percent / Bu₄NF / tetrahydrofuran / 1.5 h / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1002/hlca.200390244