2-Propanone, 1-[2-(1,3-benzodioxol-5-yl)-3,4,5-trimethoxyphenyl]-1-hydroxy-, (1R)-

Base Information

Chemical Name:2-Propanone, 1-[2-(1,3-benzodioxol-5-yl)-3,4,5-trimethoxyphenyl]-1-hydroxy-, (1R)-
CAS No.:664982-39-2
Molecular Formula:C19H20O7
Molecular Weight:360.364
Hs Code.:

Synonyms:

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Chemical Property of 2-Propanone, 1-[2-(1,3-benzodioxol-5-yl)-3,4,5-trimethoxyphenyl]-1-hydroxy-, (1R)-

Chemical Property:

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Technology Process of 2-Propanone, 1-[2-(1,3-benzodioxol-5-yl)-3,4,5-trimethoxyphenyl]-1-hydroxy-, (1R)-

There total 12 articles about 2-Propanone, 1-[2-(1,3-benzodioxol-5-yl)-3,4,5-trimethoxyphenyl]-1-hydroxy-, (1R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 664982-45-0
(R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-1-(2-methoxy-ethoxymethoxy)-propan-2-one

: 664982-39-2
(R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-1-hydroxy-propan-2-one

Guidance literature:: With pyridinium p-toluenesulfonate; In tert-butyl alcohol; at 80 ℃; for 12h;
DOI:10.1021/ol035908j

Reference yield:

: 74199-04-5
4,5,6-trimethoxy-3',4'-mehylendioxybiphenyl-2-carbaldehyde

: 664982-39-2
(R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-1-hydroxy-propan-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: CH₂Cl₂ / 3 h / 20 °C

1.2: 80 percent / K₂OsO₄*2H₂O; methanesulfonamide; potassium carbonate / (DHQD)2PHAL; K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 18 h / 0 °C

2.1: 94 percent / p-toluenesulfonic acid / CH₂Cl₂ / 20 °C

3.1: 78 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4.1: 90 percent / triethylamine / CH₂Cl₂ / 6 h / 0 °C

5.1: 88 percent / HCl / methanol / 1 h / 20 °C

6.1: 75 percent / potassium carbonate / methanol / 0.5 h / 20 °C

7.1: 83 percent / diisopropylethylamine / CH₂Cl₂ / 8 h / 20 °C

8.1: 94 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

9.1: 67 percent / pyridinium dichromate; molecular sieves 4 Angstroem / CH₂Cl₂ / 4 h

10.1: 75 percent / pyridinium p-toluenesulfonate / 2-methyl-propan-2-ol / 12 h / 80 °C

With hydrogenchloride; lithium aluminium tetrahydride; dipyridinium dichromate; 4 A molecular sieve; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; 1.1: Horner-Wadsworth-Emmons reaction / 1.2: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol035908j

Reference yield:

: 35274-53-4
2-bromo-3,4,5-tri-methoxybenzaldehyde

: 664982-39-2
(R)-1-(2-Benzo[1,3]dioxol-5-yl-3,4,5-trimethoxy-phenyl)-1-hydroxy-propan-2-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: 79 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / benzene; ethanol / 24 h / Heating

2.1: CH₂Cl₂ / 3 h / 20 °C

2.2: 80 percent / K₂OsO₄*2H₂O; methanesulfonamide; potassium carbonate / (DHQD)2PHAL; K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 18 h / 0 °C

3.1: 94 percent / p-toluenesulfonic acid / CH₂Cl₂ / 20 °C

4.1: 78 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

5.1: 90 percent / triethylamine / CH₂Cl₂ / 6 h / 0 °C

6.1: 88 percent / HCl / methanol / 1 h / 20 °C

7.1: 75 percent / potassium carbonate / methanol / 0.5 h / 20 °C

8.1: 83 percent / diisopropylethylamine / CH₂Cl₂ / 8 h / 20 °C

9.1: 94 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

10.1: 67 percent / pyridinium dichromate; molecular sieves 4 Angstroem / CH₂Cl₂ / 4 h

11.1: 75 percent / pyridinium p-toluenesulfonate / 2-methyl-propan-2-ol / 12 h / 80 °C

With hydrogenchloride; lithium aluminium tetrahydride; dipyridinium dichromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4 A molecular sieve; pyridinium p-toluenesulfonate; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; tert-butyl alcohol; benzene; 1.1: Suzuki coupling / 2.1: Horner-Wadsworth-Emmons reaction / 2.2: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol035908j