74199-04-5Relevant academic research and scientific papers
Atom-economic threefold cross-couplings of triarylbismuth reagents with 2-halobenzaldehydes and pot-economic in situ Wittig functionalizations with phosphonium salts
Rao, Maddali L. N.,Dhanorkar, Ritesh J.
, p. 63792 - 63806 (2015/02/19)
In this paper we report an efficient pot-economic methodology for the synthesis of ortho-olefinated biaryls. This has been achieved through an atom-economic threefold cross-coupling of triarylbismuth reagents with 2-halobenzaldehydes followed by pot-economic in situ Wittig olefination. The overall process is a pot-economic straightforward synthesis of ortho-olefinated biaryls from 2-halobenzaldehydes, triarylbismuth reagents and phosphonium salts. This pot-economic approach was applied to the formal synthesis of medicinally important Eupomatilone-6.
Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents
Kumar, A. Suresh,Reddy, M. Amarnath,Jain, Nishant,Kishor, Chandan,Murthy, T. Ramalinga,Ramesh, Deepa,Supriya, Bhukya,Addlagatta, Anthony,Kalivendi, Shasi V.,Sreedhar
, p. 305 - 324 (2013/03/28)
Two new series of compounds E-2,3,4-trimethoxy-6-styrylbiphenyls and 2,3,4-trimethoxy-6-(1-phenylvinyl)biphenyls were designed, synthesized and evaluated for antitubulin activity. A common intermediate 4,5,6- trimethoxybiphenyl-2-carbaldehydes was employe
Synthesis of the 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl) benzaldehyde for divergent preparation of cytotoxic biaryls
Labruere, Raphael,Helissey, Philippe,Desbene-Finck, Stephanie,Giorgi-Renault, Sylviane
, p. 568 - 571,4 (2020/09/15)
The regioselective synthesis of the 3,4,5-trimethoxy-2-(3,4-methylenedioxy- 6-nitrophenyl)benzaldehyde as key intermediate for divergent preparation of cytotoxic biaryl lignans was achieved in three steps from commercially available starting materials. Re
Synthesis and antitumor evaluation of nitrovinyl biphenyls: Anticancer agents based on allocolchicines
Jain, Nishant,Yada, Divya,Shaik, Thokhir B.,Vasantha, Galanki,Reddy, P. Surendra,Kalivendi, Shasi V.,Sreedhar
, p. 859 - 868 (2012/01/06)
A new class of nitrovinyl biphenyl compounds based on the structures of colchicines and allocolchicines were designed, synthesized, and shown to inhibit tubulin polymerization and cause mitotic arrest. A majority of these compounds were found to possess p
Nanocrystalline titania-supported palladium(0) nanoparticles for Suzuki-Miyaura cross-coupling of aryl and heteroaryl halides
Sreedhar,Yada, Divya,Reddy, P. Surendra
experimental part, p. 2823 - 2836 (2011/12/01)
The Suzuki cross-coupling reaction of various aryl and heteroaryl halides with arylboronic and heteroarylboronic acids was studied using a titania-supported palladium(0) catalyst at room temperature under air. The conversion and selectivity results obtained for many substrates were excellent and similar to those provided by more active or even homogeneous catalysts. The methodology is similarly effective using 2-bromo-3,4,5-trimethoxybenzaldehyde as the coupling partner and gave products in good yield. Furthermore, it has been shown that it is useful for the synthesis of terphenyl and tetraphenyls. The catalyst is quantitatively recovered from the reaction by simple filtration and reused for a number of cycles without significant loss of activity. Inductively coupled plasma (ICP) mass-spectrometric analysis of the filtrate from the reaction mixture demonstrated that the palladium metal hardly leached into the solution within the limits of the detector (1 ppm), thus suggesting that the present Suzuki-Miyaura reaction proceeded by heterogeneous catalysis. Copyright
Total synthesis of the eupomatilones
Mitra, Soumya,Gurrala, Srinivas Reddy,Coleman, Robert S.
, p. 8724 - 8736 (2008/03/12)
(Chemical Equation Presented) Full details of the total syntheses of five members of the eupomatilone family of lignans are reported.
The total synthesis of eupomatilones 2 and 5
Kabalka, George W.,Venkataiah, Bollu
, p. 7325 - 7328 (2007/10/03)
Efficient and diastereocontrolled syntheses of natural lignans eupomatilone 2 (1) and 5 (2) are described. Biaryl coupling was achieved using Suzuki chemistry. The lactone moiety was constructed using allylmetal reagents, which were synthesized from Bayli
Synthesis of the Putative Structure of Eupomatilone-6
Gurjar, Mukund K.,Cherian, Joseph,Ramana
, p. 317 - 319 (2007/10/03)
(Matrix presented) The synthesis of eupomatilone-6 (1) has been achieved by using Suzuki coupling, Sharpless asymmetric dihydroxylation, and intramolecular Horner-Wadsworth-Emmons reactions. The spectroscopic studies carried out on synthetic eupomatilone-
Synthesis of (-)-Steganone
Larson, Eric R.,Raphael, Ralph A.
, p. 521 - 525 (2007/10/02)
A novel, highly efficient route to the key steganone intermediate 2,3,4-trimethoxy-6,7-methylenedioxy-9-(pyrrolidin-1-yl)phenanthrene (8) is described.Resolution of the derived 5,6,7,8-tetrahydro-1,2,3-trimethoxy-10,11-methylenedioxy-8-oxodibenzocycl
