Phosphinous acid, dicyclohexyl-, (S)-phenyl-2-pyridinylmethyl ester

Base Information

• Chemical Name: Phosphinous acid, dicyclohexyl-, (S)-phenyl-2-pyridinylmethyl ester
• CAS No.: 664995-23-7
• Molecular Formula: C24H32NOP
• Molecular Weight: 381.498
• Mol file: 664995-23-7.mol

Synonyms:

Chemical Property of Phosphinous acid, dicyclohexyl-, (S)-phenyl-2-pyridinylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphinous acid, dicyclohexyl-, (S)-phenyl-2-pyridinylmethyl ester

There total 2 articles about Phosphinous acid, dicyclohexyl-, (S)-phenyl-2-pyridinylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(+)-α-phenyl-2-pyridylmethanol (5583-33-5,14159-57-0,31796-72-2,5583-34-6) + chlorodicyclohexylphosphane (16523-54-9) → P(C6H11)2OCH(C6H5)C5H4N (664995-23-7)

Guidance literature:

With potassium hydride; In diethyl ether; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1002/anie.200352755

Reference yield:

phenyl(pyridin-2-yl)methanone (91-02-1) → P(C6H11)2OCH(C6H5)C5H4N (664995-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / H₂O / 2 h / Heating

2: KH / diethyl ether; dimethylformamide / 0 - 20 °C

With sodium tetrahydroborate; potassium hydride; In diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1002/anie.200352755

Reference yield: 65.0%

P(C6H11)2OCH(C6H5)C5H4N (664995-23-7) + bis(1,5-cyclooctadiene)diiridium(I) dichloride (12112-67-3) + sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate (79060-88-1) → Ir(C8H12)P(C6H11)2OCH(C6H5)C5H4N(1+)*B(C6H3(CF3)2)4(1-)=[Ir(C8H12)P(C6H11)2OCH(C6H5)C5H4N][B(C6H3(CF3)2)4]

Guidance literature:

In dichloromethane; react. soln. of (S)-2-(α-(cycloC6H11)2PO-benzyl)pyridine in CH2Cl2with 0.5 equiv. of (Ir(cod)Cl)2 at 50 or 0-50°C, 2 h; ion exchan ge with 1.5 equiv. of sodium tetrakis(3,5-bis(trifluoromethyl)phenyl)borate in CH2Cl2, 50°C, 30 min; chromy. or crystn.;

DOI:10.1002/anie.200352755

upstream raw materials:

(S)-(+)-α-phenyl-2-pyridylmethanol

chlorodicyclohexylphosphane

phenyl(pyridin-2-yl)methanone