Carbamic acid, [2-[4-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophen yl]-1-piperazinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [2-[4-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophen yl]-1-piperazinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester
• CAS No.: 665011-62-1
• Molecular Formula: C23H32FN5O6
• Molecular Weight: 493.535
• Mol file: 665011-62-1.mol

Synonyms:

Chemical Property of Carbamic acid, [2-[4-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophen yl]-1-piperazinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [2-[4-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophen yl]-1-piperazinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [2-[4-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophen yl]-1-piperazinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate (50903-47-4) + (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide (154590-66-6,154590-43-9) → tert-butyl-(S)-(2-(4-(4-(5-(acetamidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)carbamate (665011-62-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.09.039

Reference yield:

BOC-glycine (4530-20-5) → tert-butyl-(S)-(2-(4-(4-(5-(acetamidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)carbamate (665011-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / dichloromethane / 12 h / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.bmcl.2017.09.039

Reference yield:

(S)-N-{[3-[3-fluoro-4-(N-4-tert-butoxycarbonylpiperazin-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl}acetamide (154590-65-5) → tert-butyl-(S)-(2-(4-(4-(5-(acetamidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)carbamate (665011-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 12 h / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2017.09.039

upstream raw materials:

BOC-glycine

perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate

(S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

(S)-N-{[3-[3-fluoro-4-(N-4-tert-butoxycarbonylpiperazin-1-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl}acetamide