3-AMino-4-iodobenzonitrile

Base Information

• Chemical Name: 3-AMino-4-iodobenzonitrile
• CAS No.: 665033-21-6
• Molecular Formula: C7H5IN2
• Molecular Weight: 244.03200
• Hs Code.: 2926909090
• Mol file: 665033-21-6.mol

Synonyms:CL9066;

Chemical Property of 3-AMino-4-iodobenzonitrile

Chemical Property:

• PSA: 49.81000
• LogP: 2.32628
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-4-iodobenzonitrile 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMino-4-iodobenzonitrile

There total 2 articles about 3-AMino-4-iodobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-iodo-3-nitrobenzonitrile (101420-79-5) → 3-amino-4-iodobenzonitrile (665033-21-6)

Guidance literature:

With iron; ammonium chloride; In ethanol; water;

DOI:10.3762/bjoc.13.187

Reference yield:

4-Amino 3-nitro-benzonitrile (6393-40-4) → 3-amino-4-iodobenzonitrile (665033-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; sodium iodide; sodium nitrite / dimethyl sulfoxide / 0 °C

2: tin(ll) chloride / ethanol / 3 h / 90 °C

With sulfuric acid; sodium iodide; tin(ll) chloride; sodium nitrite; In ethanol; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2011.09.018

Reference yield: 86.0%

potassium cyanate (590-28-3) + carbon monoxide (201230-82-2) + 3-amino-4-iodobenzonitrile (665033-21-6) → 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carbonitrile (1334331-27-9)

Guidance literature:

With dichloro(1,5-cyclooctadiene)palladium(II); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 70 ℃; for 24h;

DOI:10.1021/acs.orglett.5b00221

upstream raw materials:

4-iodo-3-nitrobenzonitrile

4-Amino 3-nitro-benzonitrile

Downstream raw materials:

C₉H₄F₃IN₂O

2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carbonitrile