4-Chloropyridinium chloride

Base Information

• Chemical Name: 4-Chloropyridinium chloride
• CAS No.: 7379-35-3
• Molecular Formula: C5H5Cl2N
• Molecular Weight: 150.007
• Hs Code.: 29333999
• Mol file: 7379-35-3.mol

Synonyms:4-Chloropyridinium chloride;4-chloropyridin-1-ium;chloride;AKOS015833224

Chemical Property of 4-Chloropyridinium chloride

Chemical Property:

• Appearance/Colour: White to light yellow powder
• Vapor Pressure: 5.75mmHg at 25°C
• Melting Point: 210 °C (subl.)(lit.)
• Boiling Point: 146.9 °C at 760 mmHg
• Flash Point: 52.7 °C
• PSA: 12.89000
• LogP: 2.53700
• Storage Temp.: Store below +30°C.
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 148.9799046
• Heavy Atom Count: 8
• Complexity: 50

Purity/Quality:

99% ^*data from raw suppliers

4-Chloropyridine Hydrochloride >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-36/38-20/21/22
• Safety Statements: 26-9-27-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C[NH+]=CC=C1Cl.[Cl-]
• Uses: It is employed as a catalyst in the synthesis of fluorazone derivatives by one-pot pyrrolation/cyclization of anthranilic acids.

Technology Process of 4-Chloropyridinium chloride

There total 4 articles about 4-Chloropyridinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

pyridin-4-ol (626-64-2,157061-69-3) → 4-chlorpyridine hydrochloride (7379-35-3)

Guidance literature:

With dmap; thionyl chloride; bis(trichloromethyl) carbonate; for 3.5h; Reflux; Green chemistry;

DOI:10.1021/acs.oprd.9b00407

Reference yield: 70.0%

4-aminopyridine (504-24-5) + 4-amino-1-(3-nitropyridin-4-yl)pyridinium chloride (1412913-76-8) → 3-nitro-N-(pyridin-4-yl)pyridin-4-amine + 4-chlorpyridine hydrochloride (7379-35-3)

Guidance literature:

In N,N-dimethyl-formamide; for 2h; Reflux;

DOI:10.1007/s10593-012-1127-7

Reference yield:

→ 4-chlorpyridine hydrochloride (7379-35-3)

Guidance literature:

With phosphorus trichloride; at 100 - 150 ℃; im Rohr;

upstream raw materials:

N-methyl-4-chloropyridine

4-aminopyridine

4-amino-1-(3-nitropyridin-4-yl)pyridinium chloride

pyridin-4-ol

Downstream raw materials:

2,6-Diisopropyl-4-pyridin-4-yl-phenol

4-(2-aminophenoxy)pyridine

4-phenylselenenylpyridine

4-chloro-3-iodopyridine

Refernces

• 1、 Alekseev,Kurkin,Yurovskaya. "Use of the graebe-ullmann reaction in the synthesis of 8-methyl-γ- carboline and isomeric aromatic aza-γ-carbolines". . p. 1235 - 1250. Retrieved 2013/03/13.