1-Pyridine-4-yl-piperidine-4-carboxylic acid

Base Information

• Chemical Name: 1-Pyridine-4-yl-piperidine-4-carboxylic acid
• CAS No.: 93913-86-1
• Molecular Formula: C11H14 N2 O2
• Molecular Weight: 206.244
• Hs Code.: 2933990090
• European Community (EC) Number: 674-808-2
• DSSTox Substance ID: DTXSID80917203
• Mol file: 93913-86-1.mol

Synonyms:93913-86-1;1-pyridine-4-yl-piperidine-4-carboxylic acid;1-(pyridin-4-yl)piperidine-4-carboxylic acid;1-pyridin-4-ylpiperidine-4-carboxylic Acid;1-Pyridin-4-yl-piperidine-4-carboxylic acid;1-(pyridin-4-yl)-piperidine-4-carboxylic acid;3,4,5,6-tetrahydro-2h-[1,4']bipyridinyl-4-carboxylic acid;1-(4-pyridinyl)-4-piperidinecarboxylic acid;1-(4-pyridyl)piperidine-4-carboxylic acid;MFCD08235220;4-Piperidinecarboxylic acid, 1-(4-pyridinyl)-;1-Pyridine-4-yl-piperidine-4-carboxylicacid;SCHEMBL742952;YSCH0173;N-(4-pyridyl)isonipecotic acid;N-Pyridin-4-ylisonipecotic acid;DTXSID80917203;AKOS000177996;FS-2147;SB40099;1-(pyrid-4-yl)-4-(carboxy)piperidine;1-Pyridin-4-ylpiperidin-4-carboxylic acid;4-Piperidinecarboxylicacid,1-(4-pyridinyl)-;CS-0110302;FT-0648782;1-(4-pyridinyl)piperidin-4-ylcarboxylic acid;1-(Pyridin-4-yl)piperidin-4-carboxylic acid;A844734;J-505118

Chemical Property of 1-Pyridine-4-yl-piperidine-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 2.2E-07mmHg at 25°C
• Boiling Point: 407.9°Cat760mmHg
• Flash Point: 200.5°C
• PSA: 53.43000
• Density: 1.233g/cm³
• LogP: 1.44760
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 206.105527694
• Heavy Atom Count: 15
• Complexity: 219

Purity/Quality:

97% ^*data from raw suppliers

1-(Pyridin-4-yl)piperidine-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1C(=O)O)C2=CC=NC=C2

Technology Process of 1-Pyridine-4-yl-piperidine-4-carboxylic acid

There total 4 articles about 1-Pyridine-4-yl-piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-carbethoxypiperidine (1126-09-6) + 4-chlorpyridine hydrochloride (7379-35-3) → 4-carboxy-N-(4'-pyridino) piperidine (93913-86-1)

Guidance literature:

With triethylamine; In ethanol; water; at 150 ℃; for 96h;

DOI:10.1016/S0040-4020(01)86078-6

Reference yield:

isonicotinic acid ethylester (1570-45-2) + 4-chlorpyridine hydrochloride (7379-35-3) → 4-carboxy-N-(4'-pyridino) piperidine (93913-86-1)

Guidance literature:

With triethylamine; In ethanol; water; at 150 ℃; for 96h;

Reference yield:

4-carbethoxypiperidine (1126-09-6) → 4-carboxy-N-(4'-pyridino) piperidine (93913-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol; water / 120 h / 140 °C / Sealed tube

2: sodium hydroxide / ethanol / Reflux

With triethylamine; sodium hydroxide; In ethanol; water;

DOI:10.1021/jm401169a

upstream raw materials:

4-carbethoxypiperidine

4-chlorpyridine hydrochloride

isonicotinic acid ethylester

1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester

Downstream raw materials:

1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester

1-(4-pyridinyl)piperidin-4-yl carbonyl chloride

4-hydroxymethyl-1-(pyridin-4-yl)piperidine

1-(4-bromophenylsulphonyl)-4-[1-(pyridin-4-yl)piperidin-4-ylcarbonyl]piperazine